Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

• Published in: Frontiers in pharmacology Vol. 14; p. 1278014
• Main Authors: Li, Yubing, Deng, Xinyu, Xiong, Huiling, Hu, Qichao, Chen, Yuan, Zhang, Wenwen, Ma, Xiao, Zhao, Yanling
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 16.10.2023
• Subjects: effect; multiple omics; Pharmacology; relationship; toxicity; traditional Chinese medicine

In Chinese medicine, the primary considerations revolve around toxicity and effect. The clinical goal is to achieve maximize effect while minimizing toxicity. Nevertheless, both clinical and experimental research has revealed a distinct relationship between these two patterns of action in toxic Trad...