Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

In Chinese medicine, the primary considerations revolve around toxicity and effect. The clinical goal is to achieve maximize effect while minimizing toxicity. Nevertheless, both clinical and experimental research has revealed a distinct relationship between these two patterns of action in toxic Trad...

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Published inFrontiers in pharmacology Vol. 14; p. 1278014
Main Authors Li, Yubing, Deng, Xinyu, Xiong, Huiling, Hu, Qichao, Chen, Yuan, Zhang, Wenwen, Ma, Xiao, Zhao, Yanling
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 16.10.2023
Subjects
effect
multiple omics
Pharmacology
relationship
toxicity
traditional Chinese medicine
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Abstract In Chinese medicine, the primary considerations revolve around toxicity and effect. The clinical goal is to achieve maximize effect while minimizing toxicity. Nevertheless, both clinical and experimental research has revealed a distinct relationship between these two patterns of action in toxic Traditional Chinese Medicines (TCM). These TCM often exhibit characteristic “double-sided” or “multi-faceted” features under varying pathological conditions, transitioning between effective and toxic roles. This complexity adds a layer of challenge to unraveling the ultimate objectives of Traditional Chinese medicine. To address this complexity, various hypotheses have been proposed to explain the toxicity and effect of Traditional Chinese Medicines. These hypotheses encompass the magic shrapnel theory for effect, the adverse outcome pathway framework, and the indirect toxic theory for toxicity. This review primarily focuses on high-, medium-, and low-toxicity Traditional Chinese Medicines as listed in Chinese Pharmacopoeia. It aims to elucidate the essential intrinsic mechanisms and elements contributing to their toxicity and effectiveness. The critical factors influencing the mechanisms of toxicity and effect are the optimal dosage and duration of TCM administration. However, unraveling the toxic-effect relationships in TCM presents a formidable challenge due to its multi-target and multi-pathway mechanisms of action. We propose the integration of multi-omics technology to comprehensively analyze the fundamental metabolites, mechanisms of action, and toxic effects of TCM. This comprehensive approach can provide valuable insights into the intricate relationship between the effect and toxicity of these TCM.
AbstractList In Chinese medicine, the primary considerations revolve around toxicity and effect. The clinical goal is to achieve maximize effect while minimizing toxicity. Nevertheless, both clinical and experimental research has revealed a distinct relationship between these two patterns of action in toxic Traditional Chinese Medicines (TCM). These TCM often exhibit characteristic “double-sided” or “multi-faceted” features under varying pathological conditions, transitioning between effective and toxic roles. This complexity adds a layer of challenge to unraveling the ultimate objectives of Traditional Chinese medicine. To address this complexity, various hypotheses have been proposed to explain the toxicity and effect of Traditional Chinese Medicines. These hypotheses encompass the magic shrapnel theory for effect, the adverse outcome pathway framework, and the indirect toxic theory for toxicity. This review primarily focuses on high-, medium-, and low-toxicity Traditional Chinese Medicines as listed in Chinese Pharmacopoeia. It aims to elucidate the essential intrinsic mechanisms and elements contributing to their toxicity and effectiveness. The critical factors influencing the mechanisms of toxicity and effect are the optimal dosage and duration of TCM administration. However, unraveling the toxic-effect relationships in TCM presents a formidable challenge due to its multi-target and multi-pathway mechanisms of action. We propose the integration of multi-omics technology to comprehensively analyze the fundamental metabolites, mechanisms of action, and toxic effects of TCM. This comprehensive approach can provide valuable insights into the intricate relationship between the effect and toxicity of these TCM.
Author Hu, Qichao
Li, Yubing
Chen, Yuan
Zhao, Yanling
Xiong, Huiling
Deng, Xinyu
Zhang, Wenwen
Ma, Xiao
AuthorAffiliation 1 State Key Laboratory of Southwestern Chinese Medicine Resources , School of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , China
2 Department of Pharmacy , The Fifth Medical Center of the PLA General Hospital , Beijing , China
AuthorAffiliation_xml – name: 1 State Key Laboratory of Southwestern Chinese Medicine Resources , School of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , China
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Edited by: Wirginia Kukula-Koch, Medical University of Lublin, Poland
Jia-Wen Shou, The Chinese University of Hong Kong, China
Reviewed by: Can Tu, Beijing University of Chinese Medicine, China
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SubjectTerms effect
multiple omics
Pharmacology
relationship
toxicity
traditional Chinese medicine
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Title Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review
URI https://search.proquest.com/docview/2885540788
https://pubmed.ncbi.nlm.nih.gov/PMC10617680
https://doaj.org/article/64bd428139ad4523888769b49434bf1e
Volume 14
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