Association of frailty with the serine protease HtrA1 in older adults

• Published in: Experimental gerontology Vol. 81; pp. 8 - 12
• Main Authors: Lorenzi, Maria, Lorenzi, Teresa, Marzetti, Emanuele, Landi, Francesco, Vetrano, Davide L., Settanni, Silvana, Antocicco, Manuela, Bonassi, Stefano, Valdiglesias, Vanessa, Bernabei, Roberto, Onder, Graziano
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2016
• Subjects: Aged; Aged, 80 and over; Ambulatory Care Facilities; Biomarkers; Biomarkers - blood; Female; Frail Elderly; Frailty; Geriatric Assessment - methods; High-Temperature Requirement A Serine Peptidase 1; High-temperature requirement serine protease A1; Humans; Immunosenescence; Inflammation; Inflammation - metabolism; Italy; Male; Plasma; Serine Endopeptidases - blood; High-temperature requirement serine protease A1; Biomarkers; Plasma; Frailty; Immunosenescence; Inflammation
• ISSN: 0531-5565; 1873-6815
• DOI: 10.1016/j.exger.2016.03.019

Frailty is a geriatric syndrome characterized by multi system dysregulation. It has been suggested that chronic inflammation may be involved in the pathogenesis of frailty. No study so far has identified accurate, specific and sensitive molecular biomarkers for frailty. High-temperature requirement...