Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes

• Published in: Virus research Vol. 123; no. 2; pp. 120 - 127
• Main Authors: Hayasaka, Daisuke, Maeda, Ken, Ennis, Francis A., Terajima, Masanori
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2007
• Subjects: Adenovirus; Cell Line; Cytotoxic T lymphocyte; Endothelial cell; Endothelial Cells - immunology; Endothelial Cells - metabolism; Endothelial Cells - virology; Hantavirus; Hantavirus pulmonary syndrome; Hantavirus Pulmonary Syndrome - physiopathology; Hemorrhagic fever with renal syndrome; HLA-A Antigens; Humans; Permeability; Puumala virus; Sin Nombre virus; Sin Nombre virus - immunology; Species Specificity; T-Lymphocyte Subsets - physiology; T-Lymphocytes, Cytotoxic - physiology; Transwell permeability assay; Sin Nombre virus; Hemorrhagic fever with renal syndrome; Endothelial cell; Hantavirus pulmonary syndrome; Transwell permeability assay; Cytotoxic T lymphocyte

Hantavirus infection causes two human diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. The typical feature of these diseases is increased permeability in microvascular beds in the kidneys and the lungs, respectively. The mechanism of capillary leakage, however, is n...