Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities

• Published in: Nature cancer Vol. 2; no. 9; pp. 962 - 977
• Main Authors: Tanaka, Yosuke, Chiwaki, Fumiko, Kojima, Shinya, Kawazu, Masahito, Komatsu, Masayuki, Ueno, Toshihide, Inoue, Satoshi, Sekine, Shigeki, Matsusaki, Keisuke, Matsushita, Hiromichi, Boku, Narikazu, Kanai, Yae, Yatabe, Yasushi, Sasaki, Hiroki, Mano, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.09.2021
• Subjects: Algorithms; Ascites; Cancer therapies; Chemotherapy; Gastric cancer; Genes; Genomes; Kinases; Metastasis; Mutation; Tumors; Hong Kong China; China

Peritoneal metastasis, a hallmark of incurable advanced gastric cancer (GC), presently has no curative therapy and its molecular features have not been examined extensively. Here we present a comprehensive multi-omic analysis of malignant ascitic fluid samples and their corresponding tumor cell line...