Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming

• Published in: Bioactive materials Vol. 43; pp. 48 - 66
• Main Authors: Yang, Ning, Wu, Ting, Li, Meng, Hu, Xianli, Ma, Ruixiang, Jiang, Wei, Su, Zheng, Yang, Rong, Zhu, Chen
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.01.2025; KeAi Publishing Communications Ltd; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Antibacterial activity; Antibiotics; Bacteria; Bacterial infections; Biocompatibility; Biofilms; Bone implants; Bone marrow; Cell differentiation; Coliforms; Differentiation (biology); Dopamine; Drug resistance; E coli; Ethanol; Fourier transforms; Fractures; Homeostasis; Hybridization; Inflammation; Macrophage polarization homeostasis; Macrophages; Mechanical properties; Mesenchymal stem cells; Morphology; Nanoparticles; NF-κB protein; Orthopedics; Osseointegration; Osteoclastogenesis; Osteointegration; Permeability; Porous titanium; Protective coatings; Quercetin; Scanning electron microscopy; Silver; Silver nanoparticles; Spectrum analysis; Staphylococcus infections; Stem cells; Surgical implants; Titanium; China; Osteointegration; Macrophage polarization homeostasis; Porous titanium; Silver nanoparticles; Quercetin

Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage repr...