Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming

Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage repr...

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Published inBioactive materials Vol. 43; pp. 48 - 66
Main Authors Yang, Ning, Wu, Ting, Li, Meng, Hu, Xianli, Ma, Ruixiang, Jiang, Wei, Su, Zheng, Yang, Rong, Zhu, Chen
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.01.2025
KeAi Publishing Communications Ltd
KeAi Publishing
KeAi Communications Co., Ltd
Subjects
Antibacterial activity
Antibiotics
Bacteria
Bacterial infections
Biocompatibility
Biofilms
Bone implants
Bone marrow
Cell differentiation
Coliforms
Differentiation (biology)
Dopamine
Drug resistance
E coli
Ethanol
Fourier transforms
Fractures
Homeostasis
Hybridization
Inflammation
Macrophage polarization homeostasis
Macrophages
Mechanical properties
Mesenchymal stem cells
Morphology
Nanoparticles
NF-κB protein
Orthopedics
Osseointegration
Osteoclastogenesis
Osteointegration
Permeability
Porous titanium
Protective coatings
Quercetin
Scanning electron microscopy
Silver
Silver nanoparticles
Spectrum analysis
Staphylococcus infections
Stem cells
Surgical implants
Titanium
China
Osteointegration
Macrophage polarization homeostasis
Porous titanium
Silver nanoparticles
Quercetin
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Abstract Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria (e.g., Escherichia coli, Staphylococcus aureus) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery. Schematic illustration of the design, synthesis, and biomedical applications of SQPdFT. SQPdFT is prepared by the organic-inorganic hybridization of silver nanoparticles (AgNPs) and quercetin (Que) into a polydopamine (PDA)--based coating on the 3D framework of porous titanium. Released Que can disrupt the bacterial membrane of the invading planktonic bacteria. The broken bacterial membrane can elevate the membrane permeability of AgNPs, which can further kill bacteria to inhibit biofilm formation. Importantly, released Que can terminate excessive inflammatory responses via PPARγ/NF-κB pathway-mediated regulation of macrophage polarization homeostasis. In the medullary cavity, SQPdFT has exceptional bone homeostasis repair capacity and superior mechanical stability. [Display omitted] •A novel nano-sliver/quercetin hybrid biocoating (SQPdFT) was developed.•The antibacterial performance is markedly superior to that of nano-silver coatings.•SQPdFT effectively restores bone homeostasis disrupted by excessive inflammation.•SQPdFT exhibits excellent biocompatibility and biosafety.
AbstractList Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria ( e.g., Escherichia coli , Staphylococcus aureus ) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery. Schematic illustration of the design, synthesis, and biomedical applications of SQPdFT. SQPdFT is prepared by the organic-inorganic hybridization of silver nanoparticles (AgNPs) and quercetin (Que) into a polydopamine (PDA)--based coating on the 3D framework of porous titanium. Released Que can disrupt the bacterial membrane of the invading planktonic bacteria. The broken bacterial membrane can elevate the membrane permeability of AgNPs, which can further kill bacteria to inhibit biofilm formation. Importantly, released Que can terminate excessive inflammatory responses via PPARγ/NF-κB pathway-mediated regulation of macrophage polarization homeostasis. In the medullary cavity, SQPdFT has exceptional bone homeostasis repair capacity and superior mechanical stability. Image 1 • A novel nano-sliver/quercetin hybrid biocoating (SQPdFT) was developed. • The antibacterial performance is markedly superior to that of nano-silver coatings. • SQPdFT effectively restores bone homeostasis disrupted by excessive inflammation. • SQPdFT exhibits excellent biocompatibility and biosafety.
Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria (e.g., Escherichia coli, Staphylococcus aureus) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery.
Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria (e.g., Escherichia coli, Staphylococcus aureus) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery. Schematic illustration of the design, synthesis, and biomedical applications of SQPdFT. SQPdFT is prepared by the organic-inorganic hybridization of silver nanoparticles (AgNPs) and quercetin (Que) into a polydopamine (PDA)--based coating on the 3D framework of porous titanium. Released Que can disrupt the bacterial membrane of the invading planktonic bacteria. The broken bacterial membrane can elevate the membrane permeability of AgNPs, which can further kill bacteria to inhibit biofilm formation. Importantly, released Que can terminate excessive inflammatory responses via PPARγ/NF-κB pathway-mediated regulation of macrophage polarization homeostasis. In the medullary cavity, SQPdFT has exceptional bone homeostasis repair capacity and superior mechanical stability. [Display omitted] •A novel nano-sliver/quercetin hybrid biocoating (SQPdFT) was developed.•The antibacterial performance is markedly superior to that of nano-silver coatings.•SQPdFT effectively restores bone homeostasis disrupted by excessive inflammation.•SQPdFT exhibits excellent biocompatibility and biosafety.
Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria ( , ) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery.
Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria (e.g., Escherichia coli, Staphylococcus aureus) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery.Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant infection and may induce unexpected drug resistance. Herein, a non-antibiotic strategy based on the synergy of silver ion release and macrophage reprogramming is proposed for preventing infection and bacteria-induced inflammation suppression by the organic-inorganic hybridization of silver nanoparticle (AgNP) and quercetin (Que) into a polydopamine (PDA)-based coating on the 3D framework of porous titanium (SQPdFT). Once the planktonic bacteria (e.g., Escherichia coli, Staphylococcus aureus) reach the surface of SQPdFT, released Que disrupts the bacterial membrane. Then, AgNP can penetrate the invading bacterium and kill them, which further inhibits the biofilm formation. Simultaneously, released Que can regulate macrophage polarization homeostasis via the peroxisome proliferators-activated receptors gamma (PPARγ)-mediated nuclear factor kappa-B (NF-κB) pathway, thereby terminating excessive inflammatory responses. These advantages facilitate the adhesion and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), concomitantly suppressing osteoclast maturation, and eventually conferring superior mechanical stability to SQPdFT within the medullary cavity. In summary, owing to its excellent antibacterial effect, immune remodeling function, and pro-osteointegration ability, SQPdFT is a promising protective coating for titanium-based implants used in orthopedic replacement surgery.
Author Su, Zheng
Yang, Rong
Zhu, Chen
Hu, Xianli
Li, Meng
Jiang, Wei
Ma, Ruixiang
Yang, Ning
Wu, Ting
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Keywords Osteointegration
Macrophage polarization homeostasis
Porous titanium
Silver nanoparticles
Quercetin
Language English
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Snippet Excessive inflammation caused by bacterial infection is the primary cause of implant failure. Antibiotic treatment often fails to prevent peri-implant...
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SubjectTerms Antibacterial activity
Antibiotics
Bacteria
Bacterial infections
Biocompatibility
Biofilms
Bone implants
Bone marrow
Cell differentiation
Coliforms
Differentiation (biology)
Dopamine
Drug resistance
E coli
Ethanol
Fourier transforms
Fractures
Homeostasis
Hybridization
Inflammation
Macrophage polarization homeostasis
Macrophages
Mechanical properties
Mesenchymal stem cells
Morphology
Nanoparticles
NF-κB protein
Orthopedics
Osseointegration
Osteoclastogenesis
Osteointegration
Permeability
Porous titanium
Protective coatings
Quercetin
Scanning electron microscopy
Silver
Silver nanoparticles
Spectrum analysis
Staphylococcus infections
Stem cells
Surgical implants
Titanium
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Title Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming
URI https://dx.doi.org/10.1016/j.bioactmat.2024.09.012
https://www.ncbi.nlm.nih.gov/pubmed/39318638
https://www.proquest.com/docview/3110463642
https://www.proquest.com/docview/3109431749/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC11421951
https://doaj.org/article/8e9a9c2b4ae44f2c97d91afb4154b9f4
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