Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines

• Published in: Organic & biomolecular chemistry Vol. 15; no. 17; pp. 3717 - 3727
• Main Authors: Bencze, László Csaba, Filip, Alina, Bánóczi, Gergely, Toşa, Monica Ioana, Irimie, Florin Dan, Gellért, Ákos, Poppe, László, Paizs, Csaba
• Format: Journal Article
• Language: English
• Published: England 03.05.2017
• Subjects: Petroselinum crispum

This study focuses on the expansion of the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) towards the l-enantiomers of racemic styrylalanines rac-1a-d - which are less studied and synthetically challenging unnatural amino acids - by reshaping the aromatic binding po...