Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes

• Published in: Frontiers in immunology Vol. 14; p. 1213560
• Main Authors: Koldej, Rachel M., Prabahran, Ashvind, Tan, Chin Wee, Ludford-Menting, Mandy, Morgan, Huw, Holzwart, Nicholas, Davis, Melissa J., Ritchie, David S.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 25.09.2023
• Subjects: aplastic anaemia; bone marrow; Immunology; microenvironment; poor graft function; spatial proteomics; stem cell transplant

Poor graft function (PGF), manifested by multilineage cytopenias and complete donor chimerism post-allogeneic stem cell transplantation (alloSCT), and acquired aplastic anaemia (AA) are immune-mediated acquired bone marrow (BM) failure syndromes with a similar clinical presentation. In this study, w...