Counter-proliferative effects of nucleosomal antigens in cultures from lupus patients

• Published in: Lupus Vol. 10; no. 5; pp. 332 - 339
• Main Authors: Salaman, M R, Mawer, D PC, Hogarth, M B, Seifert, M H, Isenberg, D A
• Format: Journal Article
• Language: English
• Published: Thousand Oaks, CA SAGE Publications 01.01.2001; Sage Publications Ltd
• Subjects: Adult; Antibodies; Antigens; Cell Division - drug effects; Cell Division - immunology; Cells, Cultured; Cloning; DNA - immunology; DNA - pharmacology; DNA, Single-Stranded - immunology; DNA, Single-Stranded - pharmacology; Female; Histones - immunology; Histones - pharmacology; Humans; Immunology; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - immunology; Lupus; Lupus Erythematosus, Systemic - immunology; Lymphocytes; Male; Middle Aged; Nucleosomes - immunology; Peptides; Pokeweed Mitogens; Rheumatology; Tuberculin Test; United Kingdom > UK; tuberculin; systemic lupus erythematosus; pokeweed mitogen; lymphocyte proliferation; nucleosomal antigens

Blood mononuclear cells from 20 lupus patients were cultured in the presence of nucleosomal antigens to determine whether they induce lymphocyte proliferation. The predominant effect seen, however, was one of inhibition of the background proliferation. Such inhibition was rare with cells from female...