Taq I polymorphism of the vitamin D receptor and risk of severe diabetic retinopathy

• Published in: Diabetologia Vol. 45; no. 3; pp. 436 - 442
• Main Authors: Taverna, M. J., Sola, A., Guyot-Argenton, C., Pacher, N., Bruzzo, F., Slama, G., Reach, G., Selam, J.-L.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.03.2002; Springer Nature B.V
• Subjects: Adult; Age of Onset; Biological and medical sciences; Blood pressure; C-Peptide - blood; Deoxyribonucleases, Type II Site-Specific - genetics; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - genetics; Diabetic retinopathy; Diabetic Retinopathy - epidemiology; DNA - blood; DNA - genetics; Enzymes; Female; Genotype; Humans; Insulin resistance; Insulin-like growth factors; Male; Middle Aged; Pathogenesis; Peptides; Polymerase Chain Reaction; Polymorphism; Polymorphism, Genetic; Receptors, Calcitriol - genetics; Reference Values; Restriction Mapping; Risk Factors; Vascular endothelial growth factor; Vitamin D; White people

Vitamin D, a molecule with antiproliferative, antiangiogenic, antioxidant and immunosuppressive effects, could play a role in the pathogenesis of severe diabetic retinopathy. We examined whether Taq I polymorphism of the vitamin D receptor is involved in the development of severe diabetic retinopath...