Measurement of Flow-Mediated Vasodilatation A Lesson From the FMDJ Study
The FMDJ study, a multicenter prospective observational study conducted in Japan, demonstrated the acceptable reliability of measurement of flow-mediated vasodilatation (FMD) using a semi-automatic device in individual institutions. However, in about 10% of Japanese subjects, adequate scans to deter...
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| Published in | International Heart Journal Vol. 58; no. 2; pp. 158 - 162 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
International Heart Journal Association
2017
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1349-2365 1349-3299 |
| DOI | 10.1536/ihj.17-013 |
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| Abstract | The FMDJ study, a multicenter prospective observational study conducted in Japan, demonstrated the acceptable reliability of measurement of flow-mediated vasodilatation (FMD) using a semi-automatic device in individual institutions. However, in about 10% of Japanese subjects, adequate scans to determine the brachial arterial diameter failed to be obtained. The prevalence of inadequate scans was higher in women than in men, while obesity had no influence on the inadequate scan rate. The FMDJ study also proposed that attending periodic refresher courses on the measurement of FMD is needed for maintaining competency. Finally, the FMDJ study proposed reference values for FMD. Thus, FMD measurement may be categorized as a clinically applicable tool on the basis of class IIb (exploratory cohort study with good reference standards) evidence. |
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| AbstractList | The FMDJ study, a multicenter prospective observational study conducted in Japan, demonstrated the acceptable reliability of measurement of flow-mediated vasodilatation (FMD) using a semi-automatic device in individual institutions. However, in about 10% of Japanese subjects, adequate scans to determine the brachial arterial diameter failed to be obtained. The prevalence of inadequate scans was higher in women than in men, while obesity had no influence on the inadequate scan rate. The FMDJ study also proposed that attending periodic refresher courses on the measurement of FMD is needed for maintaining competency. Finally, the FMDJ study proposed reference values for FMD. Thus, FMD measurement may be categorized as a clinically applicable tool on the basis of class IIb (exploratory cohort study with good reference standards) evidence. |
| Author | Saisu, Tomoko Tomiyama, Hirofumi Yamashina, Akira |
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| CitedBy_id | crossref_primary_10_1016_j_bj_2022_03_010 crossref_primary_10_1536_ihj_17_564 crossref_primary_10_1536_ihj_17_143 crossref_primary_10_1111_jch_13707 crossref_primary_10_1038_s41440_023_01354_3 crossref_primary_10_1016_j_ekir_2018_10_004 crossref_primary_10_1038_s41598_024_71471_7 crossref_primary_10_1007_s12325_020_01286_1 crossref_primary_10_2174_0118743641339896241011050521 crossref_primary_10_1536_ihj_17_612 |
| Cites_doi | 10.1097/HJH.0b013e328353f222 10.1016/S0735-1097(01)01746-6 10.1291/hypres.31.2019 10.1093/eurheartj/ehi017 10.1093/eurheartj/eht223 10.1016/j.atherosclerosis.2015.05.007 10.1093/eurheartj/ehq340 10.1161/HYPERTENSIONAHA.110.167015 10.1161/CIR.0b013e3182051bab 10.1253/circj.CJ-09-0534 10.1016/j.atherosclerosis.2015.08.001 10.1161/CIRCULATIONAHA.112.093245 10.1161/CIRCULATIONAHA.112.105775 10.1536/ihj.53.170 |
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| References | 11. Bots ML, Westerink J, Rabelink TJ, de Koning EJ. Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response. Eur Heart J 2005; 26: 363-8. (Review) 10. Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension 2011; 57: 363-9. (Review) 12. Charakida M, de Groot E, Loukogeorgakis SP, et al. Variability and reproducibility of flow-mediated dilatation in a multicentre clinical trial. Eur Heart J 2013; 34: 3501-7. 7. Maruhashi T, Soga J, Fujimura N, et al. Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome. Circulation 2012; 126: 598-603. 13. Ghiadoni L, Faita F, Salvetti M, et al. Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study. J Hypertens 2012; 30: 1399-405. 6. Tomiyama H, Matsumoto C, Yamada J, et al. The relationships of cardiovascular disease risk factors to flow-mediated dilatation in Japanese subjects free of cardiovascular disease. Hypertens Res 2008; 31: 2019-25. 2. Flammer AJ, Anderson T, Celermajer DS, et al. The assessment of endothelial function: from research into clinical practice. Circulation 2012; 126: 753-67. (Review) 3. Tomiyama H, Yamashina A. Non-invasive vascular function tests: their pathophysiological background and clinical application. Circ J 2010; 74: 24-33. (Review) 9. Tomiyama H, Kohro T, Higashi Y, et al. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. Atherosclerosis 2015; 242: 433-42. 5. Greenland P, Alpert JS, Beller GA, et al; American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2010; 122: 2748-64. 1. Charakida M, Masi S, Lüscher TF, Kastelein JJ, Deanfield JE. Assessment of atherosclerosis: the role of flow-mediated dilatation. Eur Heart J 2010; 31: 2854-61. (Review) 14. Corretti MC, Anderson TJ, Benjamin EJ, et al; International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-65. 4. Vlachopoulos C, Xaplanteris P, Aboyans V, et al. The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis 2015; 241: 507-32. (Review) 8. Tomiyama H, Kohro T, Higashi Y, et al. A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery. Int Heart J 2012; 53: 170-5. 11 12 13 14 1 2 3 4 5 6 7 8 9 10 |
| References_xml | – reference: 11. Bots ML, Westerink J, Rabelink TJ, de Koning EJ. Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response. Eur Heart J 2005; 26: 363-8. (Review) – reference: 4. Vlachopoulos C, Xaplanteris P, Aboyans V, et al. The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis 2015; 241: 507-32. (Review) – reference: 5. Greenland P, Alpert JS, Beller GA, et al; American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2010; 122: 2748-64. – reference: 6. Tomiyama H, Matsumoto C, Yamada J, et al. The relationships of cardiovascular disease risk factors to flow-mediated dilatation in Japanese subjects free of cardiovascular disease. Hypertens Res 2008; 31: 2019-25. – reference: 10. Green DJ, Jones H, Thijssen D, Cable NT, Atkinson G. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension 2011; 57: 363-9. (Review) – reference: 12. Charakida M, de Groot E, Loukogeorgakis SP, et al. Variability and reproducibility of flow-mediated dilatation in a multicentre clinical trial. Eur Heart J 2013; 34: 3501-7. – reference: 13. Ghiadoni L, Faita F, Salvetti M, et al. Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study. J Hypertens 2012; 30: 1399-405. – reference: 8. Tomiyama H, Kohro T, Higashi Y, et al. A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery. Int Heart J 2012; 53: 170-5. – reference: 9. Tomiyama H, Kohro T, Higashi Y, et al. Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. Atherosclerosis 2015; 242: 433-42. – reference: 1. Charakida M, Masi S, Lüscher TF, Kastelein JJ, Deanfield JE. Assessment of atherosclerosis: the role of flow-mediated dilatation. Eur Heart J 2010; 31: 2854-61. (Review) – reference: 2. Flammer AJ, Anderson T, Celermajer DS, et al. The assessment of endothelial function: from research into clinical practice. Circulation 2012; 126: 753-67. (Review) – reference: 3. Tomiyama H, Yamashina A. Non-invasive vascular function tests: their pathophysiological background and clinical application. Circ J 2010; 74: 24-33. (Review) – reference: 7. Maruhashi T, Soga J, Fujimura N, et al. Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome. Circulation 2012; 126: 598-603. – reference: 14. Corretti MC, Anderson TJ, Benjamin EJ, et al; International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-65. – ident: 13 doi: 10.1097/HJH.0b013e328353f222 – ident: 14 doi: 10.1016/S0735-1097(01)01746-6 – ident: 6 doi: 10.1291/hypres.31.2019 – ident: 11 doi: 10.1093/eurheartj/ehi017 – ident: 12 doi: 10.1093/eurheartj/eht223 – ident: 4 doi: 10.1016/j.atherosclerosis.2015.05.007 – ident: 1 doi: 10.1093/eurheartj/ehq340 – ident: 10 doi: 10.1161/HYPERTENSIONAHA.110.167015 – ident: 5 doi: 10.1161/CIR.0b013e3182051bab – ident: 3 doi: 10.1253/circj.CJ-09-0534 – ident: 9 doi: 10.1016/j.atherosclerosis.2015.08.001 – ident: 2 doi: 10.1161/CIRCULATIONAHA.112.093245 – ident: 7 doi: 10.1161/CIRCULATIONAHA.112.105775 – ident: 8 doi: 10.1536/ihj.53.170 |
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| Subtitle | A Lesson From the FMDJ Study |
| Title | Measurement of Flow-Mediated Vasodilatation |
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