Safety, Tolerability, and Pharmacokinetics of NK-104-NP: A Multicenter, Randomized, Placebo-Controlled Phase I Investigator-Initiated Trial for Intravenous Administration of Pitavastatin-Loaded PLGA Nanoparticles (NK-104-NP) in Healthy Japanese Male Subjects - Nakano, Kaku; Matoba, Tetsuya; Koga, Jun-ichiro; Kashihara, Yushi; Fukae, Masato; Ieiri, Ichiro; Shiramoto, Masanari; Irie, Shin; Kishimoto, Junji; Todaka, Koji; Egashira, Kensuke (International Heart Journal, 2018)
Keywords: Calcium; Clinical trials; Drug delivery; Drug delivery system; Drug dosages; Glycolic acid; Inflammation; Intravenous administration; Medical innovations; Nanoparticles; Nanotechnology; Pharmacokinetics; Phase I clinical trial; Population pharmacokinetic analysis; Pulmonary arteries; Pulmonary artery; Pulmonary hypertension; Statin; Stenosis