Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole

• Published in: Circulation (New York, N.Y.) Vol. 121; no. 8; pp. 979 - 988
• Main Authors: CHATURVEDI, Rajiv R, HERRON, Todd, SIMMONS, Robert, SHORE, Darryl, KUMAR, Pankaj, SETHIA, Babulal, CHUA, Felix, VASSILIADIS, Efstathios, KENTISH, Jonathan C
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 02.03.2010
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Biopsy; Blood and lymphatic vessels; Cardiology. Vascular system; Child; Child, Preschool; Collagen - metabolism; Connectin; Diastole - physiology; Dilatation, Pathologic - metabolism; Dilatation, Pathologic - physiopathology; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Elasticity - physiology; Extracellular Matrix - metabolism; Female; Heart - physiopathology; Heart Diseases - congenital; Heart Diseases - metabolism; Heart Diseases - physiopathology; Humans; Hypertrophy, Left Ventricular - metabolism; Hypertrophy, Left Ventricular - physiopathology; Infant; Male; Medical sciences; Middle Aged; Muscle Proteins - metabolism; Myocardium - metabolism; Myocardium - pathology; Protein Kinases - metabolism; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Ventricular Dysfunction, Left - metabolism; Ventricular Dysfunction, Left - physiopathology; Young Adult; titin; volume overload; heart defects; Congenital; Diastole; Cardiovascular disease; Stiffness; Congenital cardiopathy; pressure overload

In ventricular dilatation or hypertrophy, an elevated end-diastolic pressure is often assumed to be secondary to increased myocardial stiffness, but stiffness is rarely measured in vivo because of difficulty. We measured in vitro passive stiffness of volume- or pressure-overloaded myocardium mainly...