Identification of phage display peptides with affinity for the tegument of Schistosoma japonicum schistosomula

• Published in: Molecular and biochemical parasitology Vol. 180; no. 2; pp. 86 - 98
• Main Authors: Liu, Yan, Brindley, Paul J., Zeng, Qingren, Li, Yuesheng, Zhou, Jun, Chen, Yuxiao, Yang, Shenghui, Zhang, Zuping, Liu, Biyuan, Cai, Liting, McManus, Donald P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2011
• Subjects: adults; Animals; antiparasitic properties; bacteriophages; binding properties; cercariae; drugs; Ectogenic polypeptide; Female; Humans; immunohistochemistry; Kinetics; M13 phage peptide ZL4 (MppZL4); mammals; Mice; parasites; parasitology; Peptide Library; Peptides - chemistry; Peptides - metabolism; Phage display technology; polypeptides; Protein Binding; Schistosoma japonicum; Schistosoma japonicum - chemistry; Schistosoma japonicum - genetics; Schistosoma japonicum - growth & development; Schistosoma japonicum - metabolism; Schistosomiasis japonica - metabolism; Schistosomiasis japonica - parasitology; Schistosomicidal effect; schistosomula; Schistosomicidal effect; M13 phage peptide ZL4 (MppZL4); Phage display technology; Schistosoma japonicum; Ectogenic polypeptide

[Display omitted] ► M13 phage peptide ZL4 (MppZL4) was differentially screened by phage display. ► Peptide ZL4 could bind the tegument of Schistosoma japonicum schistosomula and adult but cercariae. ► MppZL4 exhibited a potent schistosomicidal effect in vitro. ► MppZL4 affected the growth and develo...