Bilingual language model for protein sequence and structure

• Published in: NAR genomics and bioinformatics Vol. 6; no. 4; p. lqae150
• Main Authors: Heinzinger, Michael, Weissenow, Konstantin, Sanchez, Joaquin Gomez, Henkel, Adrian, Mirdita, Milot, Steinegger, Martin, Rost, Burkhard
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2024
• Subjects: Amino acid sequence; Language; Metagenomics; Predictions; Protein structure; Proteins

Adapting language models to protein sequences spawned the development of powerful protein language models (pLMs). Concurrently, AlphaFold2 broke through in protein structure prediction. Now we can systematically and comprehensively explore the dual nature of proteins that act and exist as three-dime...