Conditional Deletion of the Itgb4 Integrin Gene in Schwann Cells Leads to Delayed Peripheral Nerve Regeneration

• Published in: The Journal of neuroscience Vol. 28; no. 44; pp. 11292 - 11303
• Main Authors: Van der Zee, Catharina E. E. M, Kreft, Maaike, Beckers, Gaby, Kuipers, Arthur, Sonnenberg, Arnoud
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 29.10.2008; Society for Neuroscience
• Subjects: Animals; Female; Gene Deletion; Integrin beta4 - biosynthesis; Integrin beta4 - genetics; Integrin beta4 - physiology; Male; Mice; Mice, Transgenic; Nerve Regeneration - genetics; Nerve Regeneration - physiology; Peripheral Nerves - pathology; Peripheral Nerves - physiology; Schwann Cells - pathology; Schwann Cells - physiology; Sciatic Neuropathy - genetics; Sciatic Neuropathy - metabolism; Sciatic Neuropathy - pathology; Time Factors

Several different integrins participate in the complex interactions that promote repair of the peripheral nervous system. The role of the integrin alpha6beta4 in peripheral nerve regeneration was investigated in mice by cre-mediated deletion of the Itgb4 (beta4) gene in Schwann cells. After a crush...