Polycaprolactone fibrous electrospun scaffolds reinforced with copper doped wollastonite for bone tissue engineering applications

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Vol. 109; no. 5; pp. 654 - 664
• Main Authors: Abudhahir, Mohamed, Saleem, Azeena, Paramita, Pragyan, Kumar, Sukumar Dinesh, Tze‐Wen, Chung, Selvamurugan, Nagarajan, Moorthi, Ambigapathi
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2021; Wiley Subscription Services, Inc
• Subjects: Alizarin; Alkaline phosphatase; Animals; Anti-Bacterial Agents - chemistry; Antibacterial activity; Antiinfectives and antibacterials; Apatite; Biocompatibility; Biocompatible Materials - chemistry; biocomposite scaffolds; Biomaterials; Biomedical materials; Bone and Bones - pathology; Bone biomaterials; Bone growth; Bone healing; Bone Regeneration; Calcium; Calcium Compounds - chemistry; Cbfa-1 protein; Cell Differentiation; Cell Proliferation; Collagen (type I); Composite materials; Copper; Copper - chemistry; Defects; E coli; Escherichia coli; Fourier transforms; Humans; In Vitro Techniques; Ions; Materials research; Materials science; Mesenchymal Stem Cells - cytology; Mesenchyme; Metal ions; Mice; Mice, Inbred C3H; Mineralization; Osteoblastogenesis; Osteoblasts; Osteoblasts - metabolism; Osteoconduction; Osteogenesis - drug effects; Photoelectron Spectroscopy; Polycaprolactone; Polyesters - chemistry; Protein adsorption; Proteins; Regeneration; Regeneration (physiology); Scaffolds; Scanning electron microscopy; Silicates - chemistry; Spectroscopy; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Staphylococcus aureus; Stem cell transplantation; Stem cells; Surgical implants; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds; Wollastonite; X-Ray Diffraction; bone regeneration; wollastonite; polycaprolactone; biocomposite scaffolds

The bone defects healing are always associated with post implantation infections; hence biomaterials rules significant role for orchestration of defective bone. In this study, we synthesized biocomposite scaffold by combining polycaprolactone (PCL), wollastonite (Ws) and metal ions (Cu) by electrosp...