Clinical trial: single‐ and multiple‐dose pharmacokinetics of polyethylene glycol (PEG‐3350) in healthy young and elderly subjects

• Published in: Alimentary pharmacology & therapeutics Vol. 28; no. 2; pp. 256 - 265
• Main Authors: PELHAM, R. W., NIX, L. C., CHAVIRA, R. E., CLEVELAND, M. VB, STETSON, P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2008; Blackwell
• Subjects: Adult; Age Factors; Aged; Biological and medical sciences; Chromatography, High Pressure Liquid - methods; Digestive system; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Male; Mass Spectrometry - methods; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - pharmacokinetics; Sex Factors; Multiple dose; Ethylene oxide polymer; Human; Single dose; Clinical trial; Pharmacokinetics; Elderly

Summary Background  The pharmacokinetics of polyethylene glycol 3350 (PEG‐3350) have not been fully described because of lack of a sufficiently sensitive analytical method. Aim  To describe the pharmacokinetics of PEG‐3350 in humans. Methods  A highly sensitive, high performance liquid chromatograph...