Cobalt‐containing bioactive glass mimics vascular endothelial growth factor A and hypoxia inducible factor 1 function
Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network. Among the many ions that could be incorporated, cobalt (Co) is a sign...
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Published in | Journal of biomedical materials research. Part A Vol. 109; no. 7; pp. 1051 - 1064 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.07.2021
Wiley Subscription Services, Inc |
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Abstract | Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network. Among the many ions that could be incorporated, cobalt (Co) is a significant one, as it mimics hypoxia, triggering the formation of new blood vessels by the vascular endothelial growth factor A (VEGFA), due to the stabilizing effect on the hypoxia inducible factor 1 subunit alpha (HIF1A), an activator of angiogenesis‐related genes, and is therefore of great interest for tissue engineering applications. However, despite its promising properties, the effects of glasses incorporated with Co on angiogenesis, through human umbilical cord vein endothelial cells (HUVECs) studies, need to be further investigated. Therefore, this work aimed to evaluate the biocompatibility and angiogenic potential of a new sol–gel BG, derived from the SiO2–CaO–P2O5–CoO system. The structural evaluation showed the predominance of an amorphous glass structure, and the homogeneous presence of cobalt in the samples was confirmed. in vitro experiments showed that Co‐containing glasses did not affect the viability of HUVECs, stimulated the formation of tubes and the gene expression of HIF1A and VEGFA. in vivo experiments showed that Co‐containing glasses stimulated VEGFA and HIF1A expression in blood vessels and cell nuclei, respectively, in the deep dermis layer of the dorsal region of rats, featuring considerable local stimulation of the angiogenesis process due to Co‐release. Co‐containing glasses showed therapeutic effect, and Co incorporation is a promising strategy for obtaining materials with superior angiogenesis properties for tissue engineering applications. |
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AbstractList | Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network. Among the many ions that could be incorporated, cobalt (Co) is a significant one, as it mimics hypoxia, triggering the formation of new blood vessels by the vascular endothelial growth factor A (VEGFA), due to the stabilizing effect on the hypoxia inducible factor 1 subunit alpha (HIF1A), an activator of angiogenesis-related genes, and is therefore of great interest for tissue engineering applications. However, despite its promising properties, the effects of glasses incorporated with Co on angiogenesis, through human umbilical cord vein endothelial cells (HUVECs) studies, need to be further investigated. Therefore, this work aimed to evaluate the biocompatibility and angiogenic potential of a new sol-gel BG, derived from the SiO2 -CaO-P2 O5 -CoO system. The structural evaluation showed the predominance of an amorphous glass structure, and the homogeneous presence of cobalt in the samples was confirmed. in vitro experiments showed that Co-containing glasses did not affect the viability of HUVECs, stimulated the formation of tubes and the gene expression of HIF1A and VEGFA. in vivo experiments showed that Co-containing glasses stimulated VEGFA and HIF1A expression in blood vessels and cell nuclei, respectively, in the deep dermis layer of the dorsal region of rats, featuring considerable local stimulation of the angiogenesis process due to Co-release. Co-containing glasses showed therapeutic effect, and Co incorporation is a promising strategy for obtaining materials with superior angiogenesis properties for tissue engineering applications. Abstract Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network. Among the many ions that could be incorporated, cobalt (Co) is a significant one, as it mimics hypoxia, triggering the formation of new blood vessels by the vascular endothelial growth factor A ( VEGFA ), due to the stabilizing effect on the hypoxia inducible factor 1 subunit alpha ( HIF1A ), an activator of angiogenesis‐related genes, and is therefore of great interest for tissue engineering applications. However, despite its promising properties, the effects of glasses incorporated with Co on angiogenesis, through human umbilical cord vein endothelial cells (HUVECs) studies, need to be further investigated. Therefore, this work aimed to evaluate the biocompatibility and angiogenic potential of a new sol–gel BG, derived from the SiO 2 –CaO–P 2 O 5 –CoO system. The structural evaluation showed the predominance of an amorphous glass structure, and the homogeneous presence of cobalt in the samples was confirmed. in vitro experiments showed that Co‐containing glasses did not affect the viability of HUVECs, stimulated the formation of tubes and the gene expression of HIF1A and VEGFA . in vivo experiments showed that Co‐containing glasses stimulated VEGFA and HIF1A expression in blood vessels and cell nuclei, respectively, in the deep dermis layer of the dorsal region of rats, featuring considerable local stimulation of the angiogenesis process due to Co‐release. Co‐containing glasses showed therapeutic effect, and Co incorporation is a promising strategy for obtaining materials with superior angiogenesis properties for tissue engineering applications. Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network. Among the many ions that could be incorporated, cobalt (Co) is a significant one, as it mimics hypoxia, triggering the formation of new blood vessels by the vascular endothelial growth factor A (VEGFA), due to the stabilizing effect on the hypoxia inducible factor 1 subunit alpha (HIF1A), an activator of angiogenesis‐related genes, and is therefore of great interest for tissue engineering applications. However, despite its promising properties, the effects of glasses incorporated with Co on angiogenesis, through human umbilical cord vein endothelial cells (HUVECs) studies, need to be further investigated. Therefore, this work aimed to evaluate the biocompatibility and angiogenic potential of a new sol–gel BG, derived from the SiO2–CaO–P2O5–CoO system. The structural evaluation showed the predominance of an amorphous glass structure, and the homogeneous presence of cobalt in the samples was confirmed. in vitro experiments showed that Co‐containing glasses did not affect the viability of HUVECs, stimulated the formation of tubes and the gene expression of HIF1A and VEGFA. in vivo experiments showed that Co‐containing glasses stimulated VEGFA and HIF1A expression in blood vessels and cell nuclei, respectively, in the deep dermis layer of the dorsal region of rats, featuring considerable local stimulation of the angiogenesis process due to Co‐release. Co‐containing glasses showed therapeutic effect, and Co incorporation is a promising strategy for obtaining materials with superior angiogenesis properties for tissue engineering applications. Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with physiological activities and therapeutic properties in the glass network. Among the many ions that could be incorporated, cobalt (Co) is a significant one, as it mimics hypoxia, triggering the formation of new blood vessels by the vascular endothelial growth factor A (VEGFA), due to the stabilizing effect on the hypoxia inducible factor 1 subunit alpha (HIF1A), an activator of angiogenesis-related genes, and is therefore of great interest for tissue engineering applications. However, despite its promising properties, the effects of glasses incorporated with Co on angiogenesis, through human umbilical cord vein endothelial cells (HUVECs) studies, need to be further investigated. Therefore, this work aimed to evaluate the biocompatibility and angiogenic potential of a new sol-gel BG, derived from the SiO -CaO-P O -CoO system. The structural evaluation showed the predominance of an amorphous glass structure, and the homogeneous presence of cobalt in the samples was confirmed. in vitro experiments showed that Co-containing glasses did not affect the viability of HUVECs, stimulated the formation of tubes and the gene expression of HIF1A and VEGFA. in vivo experiments showed that Co-containing glasses stimulated VEGFA and HIF1A expression in blood vessels and cell nuclei, respectively, in the deep dermis layer of the dorsal region of rats, featuring considerable local stimulation of the angiogenesis process due to Co-release. Co-containing glasses showed therapeutic effect, and Co incorporation is a promising strategy for obtaining materials with superior angiogenesis properties for tissue engineering applications. |
Author | Cunha, Pricila da Silva Queiroz‐Junior, Celso Martins Goes, Alfredo Miranda Valverde, Thalita Marcolan Miranda, Marcelo Coutinho Pereira, Marivalda Barrioni, Breno Rocha Gomes, Dawidson Assis Laia, Andréia Grossi Santos Sá, Marcos Augusto |
Author_xml | – sequence: 1 givenname: Andréia Grossi Santos orcidid: 0000-0003-0858-6061 surname: Laia fullname: Laia, Andréia Grossi Santos email: andreiagrossi@yahoo.com.br organization: Engineering School, Federal University of Minas Gerais – sequence: 2 givenname: Thalita Marcolan surname: Valverde fullname: Valverde, Thalita Marcolan organization: Institute of Biological Sciences, Federal University of Minas Gerais – sequence: 3 givenname: Breno Rocha orcidid: 0000-0002-8681-6451 surname: Barrioni fullname: Barrioni, Breno Rocha organization: Engineering School, Federal University of Minas Gerais – sequence: 4 givenname: Pricila da Silva surname: Cunha fullname: Cunha, Pricila da Silva organization: Institute of Biological Sciences, Federal University of Minas Gerais – sequence: 5 givenname: Alfredo Miranda surname: Goes fullname: Goes, Alfredo Miranda organization: Federal University of Minas Gerais – sequence: 6 givenname: Marcelo Coutinho surname: Miranda fullname: Miranda, Marcelo Coutinho organization: Institute of Biological Sciences, Federal University of Minas Gerais – sequence: 7 givenname: Dawidson Assis surname: Gomes fullname: Gomes, Dawidson Assis organization: Institute of Biological Sciences, Federal University of Minas Gerais – sequence: 8 givenname: Celso Martins surname: Queiroz‐Junior fullname: Queiroz‐Junior, Celso Martins organization: Institute of Biological Sciences, Federal University of Minas Gerais – sequence: 9 givenname: Marcos Augusto surname: Sá fullname: Sá, Marcos Augusto organization: Institute of Biological Sciences, Federal University of Minas Gerais – sequence: 10 givenname: Marivalda surname: Pereira fullname: Pereira, Marivalda organization: Engineering School, Federal University of Minas Gerais |
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Snippet | Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different ions with... Abstract Bioactive glasses (BGs) have shown great potential for tissue regeneration and their composition flexibility allows the incorporation of different... |
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SubjectTerms | Angiogenesis Animals bioactive glass Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Bioglass Biological activity Biomimetic Materials - chemistry Biomimetic Materials - pharmacology Blood vessels Cobalt Cobalt - chemistry Cobalt - pharmacology Dermis Endothelial cells Gene expression Glass - chemistry Growth factors HIF1A Human Umbilical Vein Endothelial Cells Humans Hypoxia Hypoxia-Inducible Factor 1 - analysis Incorporation Ions Male Neovascularization, Physiologic - drug effects Phosphorus pentoxide Rats Rats, Wistar Regeneration Silicon dioxide Sol-gel processes sol–gel Tissue engineering Tubes Umbilical cord Vascular endothelial growth factor Vascular Endothelial Growth Factor A - analysis VEGFA |
Title | Cobalt‐containing bioactive glass mimics vascular endothelial growth factor A and hypoxia inducible factor 1 function |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbm.a.37095 https://www.ncbi.nlm.nih.gov/pubmed/32876363 https://www.proquest.com/docview/2522393195/abstract/ https://search.proquest.com/docview/2439632571 |
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