Interleukin‐10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapy

• Published in: European journal of immunology Vol. 31; no. 12; pp. 3704 - 3713
• Main Authors: Nasser, S. M. Shuaib, Ying, Sun, Meng, Qiu, Kay, A. Barry, Ewan, Pamela W.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH 01.12.2001
• Subjects: Adult; Allergens - immunology; Allergy; Animals; Biopsy; Cytokine; Eosinophil; Female; Humans; Immunohistochemistry; Immunotherapy; In Situ Hybridization; Insect Bites and Stings - therapy; Interferon-gamma - genetics; Interleukin-10 - biosynthesis; Male; Middle Aged; RNA, Messenger - analysis; Skin - metabolism; Skin - pathology; Th1/Th2; Vespula; Wasp Venoms - immunology

We have studied the influence of wasp venom immunotherapy (VIT) on cellular recruitment and cytokine mRNA expression during allergen‐induced cutaneous late‐phase responses (LPR). Nine subjectswith a history of wasp sting anaphylaxis, and specific IgE in their sera underwent wasp VIT. Skin biopsies w...