Mammalian septins: dynamic heteromers with roles in cellular morphogenesis and compartmentalization

• Published in: The Journal of pathology Vol. 226; no. 2; pp. 287 - 299
• Main Authors: Hall, Peter A, Russell, SE Hilary
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2012
• Subjects: Animals; Bacterial Infections - genetics; Brachial Plexus Neuritis - genetics; cytoskeleton; Cytoskeleton - genetics; diffusion barrier; disease; filament; Gene Expression - genetics; Humans; Mammals; membrane; Morphogenesis - genetics; Neoplasms - genetics; Phagocytosis - genetics; polarity; Protein Isoforms - genetics; regulation; septin; Septins - genetics; Septins - metabolism; Septins - physiology; splicing; symmetry

The septins are a family of GTP‐binding proteins, evolutionarily conserved from yeast through to mammals, with roles in multiple core cellular functions. Here we provide an overview of our current knowledge of septin structure and function and focus mainly on mammalian septins, but gain much insight...