Contrasuppression. A novel immunoregulatory activity
We have described an interaction between two T cells subsets that results in interference with the expression of Ly-1-, 2+ (Ly-2) T cell-mediated suppression. We refer to this novel immunoregulatory activity as contrasuppression. The T cell responsible for the induction of contrasuppression (inducer...
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Published in | The Journal of experimental medicine Vol. 153; no. 6; pp. 1533 - 1546 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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United States
The Rockefeller University Press
01.06.1981
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Abstract | We have described an interaction between two T cells subsets that results in interference with the expression of Ly-1-, 2+ (Ly-2) T cell-mediated suppression. We refer to this novel immunoregulatory activity as contrasuppression. The T cell responsible for the induction of contrasuppression (inducer cell) expresses the phenotype Ly-1-, 2+;I-J+;Qa-1+. This phenotype distinguishes it from the suppressor effector cells which we find to be I-J-2.3. An I-J+ soluble mediator from the contrasuppressor inducer cell acts on another cell (acceptor cell) that expresses the phenotype Ly-1+, 2+; I-J+; Qa-1+. This phenotype distinguishes it from T helper cells. Both the inducer cell (or its biologically active mediator) and its acceptor cell are required for the expression of contrasuppression. Because contrasuppressor cells can block the suppressive activity of cell-free mediators released by Ly-2 suppressor T cells, the mechanism of contrasuppression is either separated from or in addition to the inactivation of suppressor cells themselves. The potential importance of contrasuppressor activity in the regulation of suppressor T cell activity in allowing immunologic memory to be expressed and in permitting microenvironmental immune regulation is discussed. |
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AbstractList | We have described an interaction between two T cells subsets that results in interference with the expression of Ly-1-, 2+ (Ly-2) T cell- mediated suppression. We refer to this novel immunoregulatory activity as contrasuppression. The T cell responsible for the induction of contrasuppression (inducer cell) expresses the phenotype Ly-1-, 2+;I- J+;Qa-1+. This phenotype distinguishes it from the suppressor effector cells which we find to be I-J-2.3. An I-J+ soluble mediator from the contrasuppressor inducer cell acts on another cell (acceptor cell) that expresses the phenotype Ly-1+, 2+; I-J+; Qa-1+. This phenotype distinguishes it from T helper cells. Both the inducer cell (or its biologically active mediator) and its acceptor cell are required for the expression of contrasuppression. Because contrasuppressor cells can block the suppressive activity of cell-free mediators released by Ly-2 suppressor T cells, the mechanism of contrasuppression is either separated from or in addition to the inactivation of suppressor cells themselves. The potential importance of contrasuppressor activity in the regulation of suppressor T cell activity in allowing immunologic memory to be expressed and in permitting microenvironmental immune regulation is discussed. The authors described an interaction between two T cell subsets that results in interference with the expression of Ly-1 super(-),2 super(+) (Ly-2) T cell-mediated suppression. They refer to this novel immunoregulatory activity as contrasuppression. The T cell responsible for the induction of contrasuppression (inducer cell) expresses the phenotype Ly-1 super(-),2 super(+); I-J super(+); Qa-1 super(+). This phenotype distinguishes it from suppressor effector cells which they find to be I-J super(-2,3). An I-J super(+) soluble mediator from the contrasuppressor inducer cell acts on another cell (acceptor cell) that expresses the phenotype Ly-1 super(+),2 super(+); I-J super(+); Qa-1 super(+). This phenotype distinguishes it from T helper cells. Both the inducer cell (or its biologically active mediator) and its acceptor cell are required for the expression of contrasuppression. Because contrasuppressor cells can block the suppressive activity of cell-free mediators released by Ly-2 suppressor T cells, the mechanism of contrasuppression is either separate from or in addition to the inactivation of suppressor cells themselves. |
Author | Gershon, R K Eardley, D D Durum, S Yamauchi, K Cantor, H Green, D R Shen, F W Murphy, D B |
Author_xml | – sequence: 1 givenname: R K surname: Gershon fullname: Gershon, R K – sequence: 2 givenname: D D surname: Eardley fullname: Eardley, D D – sequence: 3 givenname: S surname: Durum fullname: Durum, S – sequence: 4 givenname: D R surname: Green fullname: Green, D R – sequence: 5 givenname: F W surname: Shen fullname: Shen, F W – sequence: 6 givenname: K surname: Yamauchi fullname: Yamauchi, K – sequence: 7 givenname: H surname: Cantor fullname: Cantor, H – sequence: 8 givenname: D B surname: Murphy fullname: Murphy, D B |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6454751$$D View this record in MEDLINE/PubMed |
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Snippet | We have described an interaction between two T cells subsets that results in interference with the expression of Ly-1-, 2+ (Ly-2) T cell-mediated suppression.... The authors described an interaction between two T cell subsets that results in interference with the expression of Ly-1 super(-),2 super(+) (Ly-2) T... We have described an interaction between two T cells subsets that results in interference with the expression of Ly-1-, 2+ (Ly-2) T cell- mediated suppression.... |
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SubjectTerms | Animals Antigens, Surface - analysis Cell Communication Immune Tolerance Isoantibodies Lymphocyte Cooperation Lymphokines - physiology Major Histocompatibility Complex Mice T-Lymphocytes - immunology T-Lymphocytes, Regulatory - immunology |
Title | Contrasuppression. A novel immunoregulatory activity |
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