Advances in cardiac tissue engineering and heart‐on‐a‐chip

Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelle...

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Published inJournal of biomedical materials research. Part A Vol. 112; no. 4; pp. 492 - 511
Main Authors Kieda, Jennifer, Shakeri, Amid, Landau, Shira, Wang, Erika Yan, Zhao, Yimu, Lai, Benjamin Fook, Okhovatian, Sargol, Wang, Ying, Jiang, Richard, Radisic, Milica
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.04.2024
Wiley Subscription Services, Inc
Subjects
Biocompatible Materials
Biomaterials
Biomedical materials
Biotechnology
cardiac tissue engineering
cardiomyocyte
Cardiomyocytes
Cryopreservation
Elongated structure
Fabrication
Heart
heart‐on‐a‐chip
Humans
Induced Pluripotent Stem Cells
iPSC
Lab-On-A-Chip Devices
Myocardium
Myocytes, Cardiac
Phenotypes
Pluripotency
Standardization
Stem cells
Substrates
Tissue engineering
Tissue Engineering - methods
Vascularization
cardiac tissue engineering
myocardium
biomaterials
heart-on-a-chip
cardiomyocyte
iPSC
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Abstract Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell‐derived cardiac patches that advanced to human testing. Heart‐on‐a‐chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart‐on‐a‐chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.
AbstractList Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell‐derived cardiac patches that advanced to human testing. Heart‐on‐a‐chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart‐on‐a‐chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.
Abstract Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell‐derived cardiac patches that advanced to human testing. Heart‐on‐a‐chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart‐on‐a‐chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.
Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell-derived cardiac patches that advanced to human testing. Heart-on-a-chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart-on-a-chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell-derived cardiac patches that advanced to human testing. Heart-on-a-chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart-on-a-chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.
Author Wang, Erika Yan
Landau, Shira
Shakeri, Amid
Kieda, Jennifer
Wang, Ying
Jiang, Richard
Lai, Benjamin Fook
Zhao, Yimu
Radisic, Milica
Okhovatian, Sargol
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crossref_primary_10_3390_biomedicines12061190
crossref_primary_10_3389_fbioe_2024_1385124
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2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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ISSN 1549-3296
1552-4965
IngestDate Sat Aug 17 04:39:32 EDT 2024
Fri Sep 13 04:26:49 EDT 2024
Thu Sep 26 17:27:35 EDT 2024
Wed Oct 02 05:25:02 EDT 2024
Sat Aug 24 00:53:55 EDT 2024
IsDoiOpenAccess true
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Issue 4
Keywords cardiac tissue engineering
myocardium
biomaterials
heart-on-a-chip
cardiomyocyte
iPSC
Language English
License Attribution
2023 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals LLC.
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Notes Jennifer Kieda and Amid Shakeri: Equal contribution.
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Snippet Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of innovative...
Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new biomaterial development as well as the employment of innovative...
Abstract Recent advances in both cardiac tissue engineering and hearts‐on‐a‐chip are grounded in new biomaterial development as well as the employment of...
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SubjectTerms Biocompatible Materials
Biomaterials
Biomedical materials
Biotechnology
cardiac tissue engineering
cardiomyocyte
Cardiomyocytes
Cryopreservation
Elongated structure
Fabrication
Heart
heart‐on‐a‐chip
Humans
Induced Pluripotent Stem Cells
iPSC
Lab-On-A-Chip Devices
Myocardium
Myocytes, Cardiac
Phenotypes
Pluripotency
Standardization
Stem cells
Substrates
Tissue engineering
Tissue Engineering - methods
Vascularization
Title Advances in cardiac tissue engineering and heart‐on‐a‐chip
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjbm.a.37633
https://www.ncbi.nlm.nih.gov/pubmed/37909362
https://www.proquest.com/docview/2926524716/abstract/
https://www.proquest.com/docview/2885206780/abstract/
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