STAT3 as a mediator of BCR-ABL1-independent resistance in chronic myeloid leukemia
Keywords: TKI resistance, BCR-ABL1-independent resistance, BCR-ABL1-dependent resistance, CML stem cell, STAT3, pSTAT3[sup.Y705], BP-5-087
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| Published in | Leukemia Vol. 3; no. Suppl 1; pp. S5 - S6 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.12.2014
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Keywords: TKI resistance, BCR-ABL1-independent resistance, BCR-ABL1-dependent resistance, CML stem cell, STAT3, pSTAT3[sup.Y705], BP-5-087 |
|---|---|
| AbstractList | Keywords: TKI resistance, BCR-ABL1-independent resistance, BCR-ABL1-dependent resistance, CML stem cell, STAT3, pSTAT3[sup.Y705], BP-5-087 |
| Audience | Academic |
| Author | Kraft, I L Page, B D Deininger, M W Eiring, A M O'Hare, T Gunning, P T |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27175272$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.1062538 10.1016/S1535-6108(02)00096-X 10.1182/blood-2012-02-412890 10.1186/1756-8722-4-6 10.1158/0008-5472.CAN-12-3955 10.1158/1535-7163.MCT-08-0314 10.1182/blood.V99.1.319 10.1172/JCI35721 |
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| Keywords | CML stem cell BP-5-087 BCR-ABL1-independent resistance STAT3 BCR-ABL1-dependent resistance pSTAT3 TKI resistance pSTAT3Y705 |
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| References_xml | – volume: 293 start-page: 876 year: 2001 end-page: 880 ident: CR1 article-title: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification publication-title: Science doi: 10.1126/science.1062538 contributor: fullname: Rao – volume: 2 start-page: 117 year: 2002 end-page: 125 ident: CR2 article-title: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00096-X contributor: fullname: Kuriyan – volume: 121 start-page: 1824 year: 2013 end-page: 1838 ident: CR4 article-title: Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-beta-catenin signaling publication-title: Blood doi: 10.1182/blood-2012-02-412890 contributor: fullname: Campana – volume: 4 start-page: 6 year: 2011 ident: CR6 article-title: BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance publication-title: J Hematol Oncol doi: 10.1186/1756-8722-4-6 contributor: fullname: Drexler – volume: 73 start-page: 2052 year: 2013 end-page: 2058 ident: CR5 article-title: Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem/progenitor cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-3955 contributor: fullname: Roy – volume: 7 start-page: 3169 year: 2008 end-page: 3175 ident: CR3 article-title: Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-08-0314 contributor: fullname: Hazlehurst – volume: 99 start-page: 319 year: 2002 end-page: 325 ident: CR7 article-title: Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 publication-title: Blood doi: 10.1182/blood.V99.1.319 contributor: fullname: Richmond – volume: 121 start-page: 396 year: 2011 end-page: 409 ident: CR8 article-title: Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity publication-title: J Clin Invest doi: 10.1172/JCI35721 contributor: fullname: Druker – volume: 7 start-page: 3169 year: 2008 ident: BFleusup20143_CR3 publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-08-0314 contributor: fullname: NN Bewry – volume: 121 start-page: 1824 year: 2013 ident: BFleusup20143_CR4 publication-title: Blood doi: 10.1182/blood-2012-02-412890 contributor: fullname: B Zhang – volume: 2 start-page: 117 year: 2002 ident: BFleusup20143_CR2 publication-title: Cancer Cell doi: 10.1016/S1535-6108(02)00096-X contributor: fullname: NP Shah – volume: 121 start-page: 396 year: 2011 ident: BFleusup20143_CR8 publication-title: J Clin Invest doi: 10.1172/JCI35721 contributor: fullname: AS Corbin – volume: 99 start-page: 319 year: 2002 ident: BFleusup20143_CR7 publication-title: Blood doi: 10.1182/blood.V99.1.319 contributor: fullname: SM Graham – volume: 293 start-page: 876 year: 2001 ident: BFleusup20143_CR1 publication-title: Science doi: 10.1126/science.1062538 contributor: fullname: ME Gorre – volume: 4 start-page: 6 year: 2011 ident: BFleusup20143_CR6 publication-title: J Hematol Oncol doi: 10.1186/1756-8722-4-6 contributor: fullname: H Quentmeier – volume: 73 start-page: 2052 year: 2013 ident: BFleusup20143_CR5 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-3955 contributor: fullname: L Casetti |
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| Title | STAT3 as a mediator of BCR-ABL1-independent resistance in chronic myeloid leukemia |
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