Design and characterization of biodegradable multi layered electrospun nanofibers for corneal tissue engineering applications

• Published in: Journal of biomedical materials research. Part A Vol. 107; no. 10; pp. 2340 - 2349
• Main Authors: Arabpour, Zohreh, Baradaran‐Rafii, Alireza, Bakhshaiesh, Nasrin L., Ai, Jafar, Ebrahimi‐Barough, Somayeh, Esmaeili Malekabadi, Hossein, Nazeri, Niloofar, Vaez, Ahmad, Salehi, Majid, Sefat, Farshid, Ostad, Seyed N.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2019; Wiley Subscription Services, Inc
• Subjects: Biodegradability; Biodegradation; Carbodiimide; Cell adhesion; Cell proliferation; collagen; Collagen (type I); Contact angle; Cornea; corneal; Degradation; Design; Electrospinning; Endometrium; Fourier transforms; Glutaraldehyde; human endometrial stem cells (hEnSCs); In vitro methods and tests; Infrared analysis; Infrared spectroscopy; Mechanical properties; Medical treatment; Nanofibers; PLGA; Polylactide-co-glycolide; Regeneration; Research projects; Scaffolds; Scanning electron microscopy; Scanning transmission electron microscopy; Shrinkage; Stem cells; Substrates; Tensile tests; Tissue engineering; Ultrasonic testing; Viability; collagen; tissue engineering; PLGA; corneal; human endometrial stem cells (hEnSCs); electrospinning

Tissue engineering is one of the most promising areas for treatment of various ophthalmic diseases particularly for patients who suffer from limbal stem cell deficiency and this is due to the lack of existence of appropriate matrix for stem cell regeneration. The aim of this research project is to d...