Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient
Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a...
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| Published in | Blood coagulation & fibrinolysis Vol. 23; no. 1; p. 69 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2012
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and was treated successfully with rFVIIa and steroid therapy, but was complicated with a life-threatening thromboembolic attack during follow-up. |
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| AbstractList | Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and was treated successfully with rFVIIa and steroid therapy, but was complicated with a life-threatening thromboembolic attack during follow-up. |
| Author | Pişkin, Ozden Katgi, Abdullah Ataca, Pinar Kahraman, Selda Ozsan, Güner H Ozcan, Mehmet A Demirkan, Fatih Undar, Bülent |
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| SubjectTerms | Aged Brain Ischemia - chemically induced Factor VIIa - adverse effects Factor VIIa - therapeutic use Hemophilia A - drug therapy Humans Male Meta-Analysis as Topic Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Stroke - chemically induced |
| Title | Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient |
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