Minireview: The Role of Nuclear Receptors in Photoreceptor Differentiation and Disease

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 26; no. 6; pp. 905 - 915
• Main Authors: Forrest, Douglas, Swaroop, Anand
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.06.2012; Endocrine Society
• Subjects: Animals; Cell Differentiation; Eye Diseases - metabolism; Eye Diseases - pathology; Gene Expression Regulation; Humans; Ligands; Minireview; Mutation; Phenotype; Photoreceptor Cells - metabolism; Photoreceptor Cells - physiology; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, Cytoplasmic and Nuclear - physiology; Signal Transduction; Vision, Ocular; PNR | TLX | TR-β | ERR-β | ROR-α | ROR-β | RXR-γ | RXR-α | RAR-β | RAR-γ | COUP-TFII | COUPTFI

Abstract Rod and cone photoreceptors are specialized sensory cells that mediate vision. Transcriptional controls are critical for the development and long-term survival of photoreceptors; when these controls become ineffective, retinal dysfunction or degenerative disease may result. This review disc...