DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions

• Published in: Mechanisms of ageing and development Vol. 213; p. 111836
• Main Authors: Pramotton, Francesca M., Abukar, Asra, Hudson, Chantelle, Dunbar, James, Potterton, Andrew, Tonnicchia, Simone, Taddei, Andrea, Mazza, Edoardo, Giampietro, Costanza
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.07.2023
• Subjects: Adherens junctions; DYRK1B; Endothelial dysfunction; Endothelial senescence; Vascular permeability; Endothelial dysfunction; DYRK1B; Adherens junctions; Vascular permeability; Endothelial senescence

Aging is the major risk factor for chronic disease development. Cellular senescence is a key mechanism that triggers or contributes to age-related phenotypes and pathologies. The endothelium, a single layer of cells lining the inner surface of a blood vessel, is a critical interface between blood an...