Gastric antisecretory and antiulcer activity of bovine hemoglobin

• Published in: World journal of gastroenterology : WJG Vol. 19; no. 21; pp. 3291 - 3299
• Main Authors: Al Asmari, Abdulrahman K, Al Omani, Saud, Elfaki, Ibrahim, Tariq, Mohammad, Al Malki, Ahmed, Al Asmary, Saeed
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 07.06.2013
• Subjects: Animals; Anti-Ulcer Agents - pharmacology; Brief; Cattle; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid - secretion; Gastric Mucosa - drug effects; Gastric Mucosa - pathology; Gastric Mucosa - secretion; Hemoglobins - pharmacology; Indomethacin; Male; Neutrophils - drug effects; Neutrophils - metabolism; Oxidative Stress - drug effects; Peroxidase - metabolism; Rats; Rats, Wistar; Stomach Ulcer - metabolism; Stomach Ulcer - pathology; Stomach Ulcer - prevention & control; Sulfhydryl Compounds - metabolism; Time Factors; Rats; Indomethacin; Bovine hemoglobin; Ethanol; Ischemic injury; Gastric ulcers

To investigate gastric antisecretory and gastroprotective activity of bovine hemoglobin (B-Hb) in rats. Adult Albino-Wistar rats were divided into groups of 6 animals each. B-Hb in doses of 100, 300 and 900 mg/kg body weight was tested for gastric acid secretion and antiulcer activity. Gastric secre...