Cerebral Blood Flow in Polytrauma: Transcranial Doppler Analysis in a Nonhuman Primate Shock Model

• Published in: The Journal of surgical research Vol. 232; pp. 146 - 153
• Main Authors: Pratt, Gilbert Andrew, Hathaway, Emily N., Hemond, Peter J., Tadaki, Douglas K., Sheppard, Forest R., Glaser, Jacob J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2018
• Subjects: Animals; Blood flow; Blood Flow Velocity; Cerebral perfusion; Cerebrovascular Circulation - physiology; Disease Models, Animal; Hemodynamics; Hemorrhagic shock; Macaca mulatta; Male; Multiple Trauma - diagnostic imaging; Multiple Trauma - physiopathology; Polytrauma; Shock, Hemorrhagic - diagnostic imaging; Shock, Hemorrhagic - physiopathology; Transcranial Doppler; Ultrasonography, Doppler, Transcranial - methods; Hemorrhagic shock; Polytrauma; Cerebral perfusion; Transcranial Doppler; Blood flow

In combat-related trauma, resuscitation goals are to attenuate tissue hypoxia and maintain circulation. During hemorrhagic shock, compensatory and autoregulatory mechanisms are activated to preserve cerebral blood flow. Transcranial Doppler (TCD) ultrasonography may be an ideal noninvasive modality...