PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma

• Published in: Oncotarget Vol. 6; no. 13; pp. 10880 - 10892
• Main Authors: Leung, Carmen Oi-ning, Wong, Carmen Chak-lui, Fan, Dorothy Ngo-yin, Kai, Alan Ka-lun, Tung, Edmund Kwok-kwan, Xu, Iris Ming-jing, Ng, Irene Oi-lin, Lo, Regina Cheuk-lam
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 10.05.2015
• Subjects: Active Transport, Cell Nucleus; Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - secondary; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Liver Neoplasms - enzymology; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Phosphorylation; Proteasome Endopeptidase Complex - metabolism; Proteolysis; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-pim-1 - genetics; Proto-Oncogene Proteins c-pim-1 - metabolism; Research Paper; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Burden; Up-Regulation; PIM1; metastasis; HCC

Hepatocellular carcinoma (HCC) is characteristically one of the most rapidly proliferating tumors which outgrows functional blood supply and results in regional oxygen deprivation. Overexpression of PIM1, a serine/threonine kinase, has been identified recently in human cancers. Knowledge on PIM1 in...