A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake

• Published in: American journal of physiology: endocrinology and metabolism Vol. 275; no. 1; pp. E101 - E111
• Main Authors: Galassetti, Pietro, Shiota, Masakazu, Zinker, Brad A, Wasserman, David H, Cherrington, Alan D
• Format: Journal Article
• Language: English
• Published: United States 01.07.1998
• Subjects: Animals; Blood Glucose - drug effects; Blood Glucose - metabolism; Dogs; Female; Glucagon - administration & dosage; Glucagon - blood; Glucagon - pharmacology; Glucose - metabolism; Hepatic Artery - physiology; Hindlimb; Hyperglycemia - metabolism; Iliac Artery - physiology; Iliac Vein - physiology; Infusions, Intravenous; Insulin - administration & dosage; Insulin - blood; Insulin - pharmacology; Liver - metabolism; Liver Circulation - physiology; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiology; Portal System - physiology; Portal Vein - physiology; Regional Blood Flow; Somatostatin - administration & dosage; Somatostatin - blood; Somatostatin - pharmacology

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615 The effect of a negative arterial-portal venous (a-pv) glucose gradient on skeletal muscle and whole body nonhepatic glucose uptake was studied in 12 42-h-fasted conscious dog...