Long-term experience in percutaneous transluminal dilatation of renal artery stenosis

• Published in: The American journal of medicine Vol. 79; no. 6; pp. 692 - 698
• Main Authors: Kuhlmann, Ulrich, Greminger, Peter, Gruntzig, Andreas, Schneider, Ernst, Pouliadis, Grigorios, Lüscher, Thomas, Steurer, Johann, Siegenthaler, Walter, Vetter, Wilhelm
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1985; Elsevier
• Subjects: Adult; Angiography; Angioplasty, Balloon; Arteriosclerosis - complications; Biological and medical sciences; Blood Pressure; Female; Fibromuscular Dysplasia - complications; Follow-Up Studies; Humans; Hypertension, Renovascular - therapy; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Renal Artery - diagnostic imaging; Renal Artery Obstruction - etiology; Renal Artery Obstruction - therapy; Renin - blood; Renovascular diseases; Time Factors; Human; Urinary system disease; Renal artery; Stenosis; Instrumentation therapy; Cardiovascular disease; Instrumental dilatation; Percutaneous route
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/0002-9343(85)90519-4

Percutaneous transluminal dilatation was attempted in 65 patients with renovascular hypertension. In five cases (8 percent), percutaneous transluminal dilatation could not be performed for technical reasons. In the remaining 60 patients (35 with atherosclerotic stenosis and 25 with fibromuscular dysplasia), both mean systolic and diastolic pressure fell immediately after percutaneous transluminal dilatation and remained significantly lower for a period of up to five years. Cure rates after a mean control period of 21.6 months were higher in patients with fibromuscular dysplasia (50 percent) than in those with atherosclerotic stenosis (29 percent). Improvement of blood pressure was observed in 32 percent of patients with fibromuscular dysplasia and in 48 percent of patients with atherosclerotic stenosis. Follow-up angiography in 33 cases showed occlusion of the dilated artery in two patients and recurrence of slight renal artery stenosis in nine patients. Successful redilatation could be performed in five of these cases. Furthermore, renal vein renin determinations were only of limited diagnostic or prognostic value. These results document the good long-term effect of percutaneous transluminal dilatation in patients with renal artery stenosis. Percutaneous transluminal dilatation should, therefore, be the favored procedure in patients with renovascular hypertension.