Design, Synthesis and Radioprotective Activity Evaluation of Novel N-Phenyl-2H-chromene-3-carboxamides Derived from Ex-RAD

• Published in: Chemical & pharmaceutical bulletin Vol. 73; no. 7; pp. 600 - 615
• Main Authors: Liu, Xin-Ru, Feng, Han-Yin, Liu, Xiao-Han, Xu, Jing, Liu, Shu-Chen, Zhang, Shou-Guo, Peng, Tao
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 10.07.2025; Japan Science and Technology Agency
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Bcl-2 protein; Benzopyrans - chemical synthesis; Benzopyrans - chemistry; Benzopyrans - pharmacology; Blood cells; DNA damage; DNA Damage - drug effects; Dose-Response Relationship, Drug; Drug Design; Exposure; Gene sequencing; Humans; Intestine; Ionizing radiation; Kinases; Male; MAP kinase; Mice; Mitogen-Activated Protein Kinases - chemistry; Mitogen-Activated Protein Kinases - metabolism; Molecular Structure; N-phenyl-2H-chromene-3-carboxamide; p53 Protein; Peripheral blood; Proteins; Radiation; radiation countermeasure; Radiation damage; Radiation effects; Radiation protection; Radiation-Protective Agents - chemical synthesis; Radiation-Protective Agents - chemistry; Radiation-Protective Agents - pharmacology; radioprotection; Sequence analysis; Signal transduction; Small intestine; Structure-Activity Relationship; Whole-Body Irradiation; Wnt protein; radiation countermeasure; N-phenyl-2H-chromene-3-carboxamide; radioprotection

Exposures to ionizing radiation can cause serious damages to human body, and the development of radiation countermeasures is urgently needed. In this paper, a series of N-phenyl-2H-chromene-3-carboxamides were designed and synthesized as potential radiation countermeasures. Their radioprotective act...