Design, Synthesis and Radioprotective Activity Evaluation of Novel N-Phenyl-2H-chromene-3-carboxamides Derived from Ex-RAD - Liu, Xin-Ru; Feng, Han-Yin; Liu, Xiao-Han; Xu, Jing; Liu, Shu-Chen; Zhang, Shou-Guo; Peng, Tao (Chemical & pharmaceutical bulletin, 2025)
Keywords: Animals; Apoptosis; Apoptosis - drug effects; Bcl-2 protein; Benzopyrans - chemical synthesis; Benzopyrans - chemistry; Benzopyrans - pharmacology; Blood cells; DNA damage; DNA Damage - drug effects; Dose-Response Relationship, Drug; Drug Design; Exposure; Gene sequencing; Humans; Intestine; Ionizing radiation; Kinases; Male; MAP kinase; Mice; Mitogen-Activated Protein Kinases - chemistry; Mitogen-Activated Protein Kinases - metabolism; Molecular Structure; N-phenyl-2H-chromene-3-carboxamide; p53 Protein; Peripheral blood; Proteins; Radiation; radiation countermeasure; Radiation damage; Radiation effects; Radiation protection; Radiation-Protective Agents - chemical synthesis; Radiation-Protective Agents - chemistry; Radiation-Protective Agents - pharmacology; radioprotection; Sequence analysis; Signal transduction; Small intestine; Structure-Activity Relationship; Whole-Body Irradiation; Wnt protein; radiation countermeasure; N-phenyl-2H-chromene-3-carboxamide; radioprotection