Multiparametric monitoring of chemotherapy treatment response in locally advanced breast cancer using quantitative ultrasound and diffuse optical spectroscopy

• Published in: Oncotarget Vol. 7; no. 15; pp. 19762 - 19780
• Main Authors: Tran, William T., Childs, Charmaine, Chin, Lee, Slodkowska, Elzbieta, Sannachi, Lakshmanan, Tadayyon, Hadi, Watkins, Elyse, Wong, Sharon Lemon, Curpen, Belinda, Kaffas, Ahmed El, Al-Mahrouki, Azza, Sadeghi-Naini, Ali, Czarnota, Gregory J.
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 12.04.2016
• Subjects: Adult; Aged; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Chemotherapy, Adjuvant; Female; Hemoglobins - analysis; Humans; Logistic Models; Middle Aged; Monitoring, Physiologic - methods; Multivariate Analysis; Optical Imaging - methods; Outcome Assessment, Health Care - methods; Reproducibility of Results; Research Paper; ROC Curve; Spectrum Analysis - methods; Ultrasonography - methods; quantitative ultrasound; neoadjuvant chemotherapy; locally advanced breast cancer; treatment monitoring; diffuse optical spectroscopy

This study evaluated pathological response to neoadjuvant chemotherapy using quantitative ultrasound (QUS) and diffuse optical spectroscopy imaging (DOSI) biomarkers in locally advanced breast cancer (LABC). The institution's ethics review board approved this study. Subjects (n = 22) gave writt...