Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects

• Published in: Clinical microbiology and infection Vol. 26; no. 5; pp. 645.e1 - 645.e8
• Main Authors: Subissi, L., Rodeghiero, C., Martini, H., Litzroth, A., Huygen, K., Leroux-Roels, G., Piérard, D., Desombere, I.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2020
• Subjects: ACT; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antibodies, Bacterial - blood; Antibody; Antigens, Bacterial - immunology; Bordetella pertussis; Bordetella pertussis - immunology; Child; Female; Humans; IgA; Immunoglobulin A - blood; Immunoglobulin G - blood; Male; Middle Aged; Pertussis toxin; Pertussis Toxin - immunology; Pertussis Vaccine - administration & dosage; Pertussis Vaccine - immunology; Sensitivity and Specificity; Serodiagnosis; Serologic Tests - methods; Serology; Vaccination; Whooping Cough - blood; Whooping Cough - diagnosis; Whooping Cough - pathology; Whooping Cough - prevention & control; Young Adult; ACT; IgA; Antibody; Vaccination; Serology; Bordetella pertussis; Serodiagnosis; Pertussis toxin

Quantifying IgG antibodies to pertussis toxin (PT) is the most specific and sensitive method for the serodiagnosis of a Bordetella pertussis infection. Since PT is a component of acellular pertussis vaccines, anti-PT IgG is also induced by vaccination, precluding pertussis serodiagnosis based exclus...