An identification and functional evaluation of a novel CYP2C9 variant CYP2C962

• Published in: Chemico-biological interactions Vol. 327; p. 109168
• Main Authors: Chen, Hao, Dai, Da-Peng, Zhou, Shan, Liu, Jian, Wang, Shuang-Hu, Wu, Hua-Lan, Zhou, Quan, Geng, Pei-Wu, Chong, Jia, Lü, You, Cai, Jian-Ping, Yang, Jie-Fu
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.08.2020
• Subjects: Allelic variant; CYP2C9; Drug metabolism; Functional analysis in vitro; Drug metabolism; CYP2C9; Functional analysis in vitro; Allelic variant

Warfarin is the most commonly used anticoagulant in the clinical treatment of thromboembolic diseases. The dose of warfarin varies significantly within populations, and the dose is closely related to the genetic polymorphisms of the CYP2C9 and VKORC1 genes. In this study, a new CYP2C9 nonsynonymous...