High doses of carbamazepine for refractory partial epilepsy
Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and fifteen on polytherapy. The other drugs were kept unchanged in the patients on polytherapy. The dose of CBZ was increased if no control was ob...
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| Published in | Arquivos de neuro-psiquiatria Vol. 54; no. 1; pp. 42 - 46 |
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| Format | Journal Article |
| Language | English |
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01.03.1996
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| Abstract | Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and fifteen on polytherapy. The other drugs were kept unchanged in the patients on polytherapy. The dose of CBZ was increased if no control was observed and the patient had no side effects. The doses used ranged between 1200 and 1900 mg/day (1200 mg/day, n = 18; 1300 mg/day, n = 1; 1400 mg/day, n = 7; 1600 mg/day, n = 9; 1700 mg/day, n = 4; 1800 mg/day, n = 8; 1900 mg/day, n = 1). Anticonvulsant plasma levels were taken to confirm patient compliance. The average plasma level was 9.6 ug/mL. The period of follow up varied from 3 to 96 months (M = 25.6). Seizure's control was observed in 7 (14.48%) patients taking 1200 mg/day and in 2 (4.16%) patients taking 1400 mg/day of CBZ. Thirty-nine patients did not show any control (81.21%). Ten patients (20.81%) had signs of intoxication. When patients have no improvement with 1400 mg/day, it is difficult to obtain any control despite the use of higher doses of CBZ, which frequently expose the patient to significant side effects. |
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| AbstractList | Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and fifteen on polytherapy. The other drugs were kept unchanged in the patients on polytherapy. The dose of CBZ was increased if no control was observed and the patient had no side effects. The doses used ranged between 1200 and 1900 mg/day (1200 mg/day, n=18; 1300mg/day, n=1; 1400 mg/day, n=7; 1600 mg/day, n=9; 1700 mg/day, n=4; 1800 mg/day, n=8; 1900 mg/day, n=1). Anticonvulsant plasma levels were taken to confirm patient compliance. The average plasma level was 9.6 ug/mL. The period of follow up varied from 3 to 96 months (M=25.6). Seizure's control was observed in 7 (14.48%) patients taking 1200 mg/day and in 2 (4.16%) patients taking 1400 mg/day of CBZ. Thirty-nine patients did not show any control (81.21%). Ten patients (20.81%) had signs of intoxication. When patients have no improvement with 1400 mg/day, it is difficult to obtain any control despite the use of higher doses of CBZ, which frequently expose the patient to significant side effects.
Foram analisados 48 pacientes epilépticos com crises parciais que faziam uso de carbamazepina (CBZ) em doses iguais ou superiores a 1200 mg por dia. Trinta e três estavam em monoterapia e 15 em politerapia. As outras medicações foram mantidas constantes durante a manipulação da dose de CBZ nos pacientes em politerapia. O critério utilizado para o aumento da dose de CBZ foi a falta de controle clínico e a ausência de efeitos colaterais (independente da dosagem sérica). A dose máxima variou de 1200 a 1900 mg/dia (1200 mg, n=18; 1300 mg/dia, n=1; 1400 mg/dia, n=7; 1600 mg/dia, n=9; 1700 mg/dia, n=4; 1800 mg/dia, n=8 ; 1900 mg/dia, n=1). Dosagens séricas de anticonvulsivantes eram utilizadas no sentido de confirmar a aderência ao tratamento. A média das dosagens disponíveis foi de 9,6 ug/mL. O tempo de seguimento variou de 3 a 96 meses (M=25,6). Houve controle das crises em 7 (14,48 %) pacientes com 1200 mg/dia e em 2 (4, 16 %) pacientes com 1400 mg/dia. Trinta e nove pacientes nao obtiveram controle (81,21%). Dez pacientes (20,81 %) mostraram sinais de intoxicação. Quando doses de CBZ até 1400 mg não são eficazes, doses mais altas da droga são frequentemente incapazes de controlar as crises epilépticas. Nesta situação, a chance de intoxicação aumenta significativamente sem que haja beneficios para o paciente. Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and fifteen on polytherapy. The other drugs were kept unchanged in the patients on polytherapy. The dose of CBZ was increased if no control was observed and the patient had no side effects. The doses used ranged between 1200 and 1900 mg/day (1200 mg/day, n=18; 1300mg/day, n=1; 1400 mg/day, n=7; 1600 mg/day, n=9; 1700 mg/day, n=4; 1800 mg/day, n=8; 1900 mg/day, n=1). Anticonvulsant plasma levels were taken to confirm patient compliance. The average plasma level was 9.6 ug/mL. The period of follow up varied from 3 to 96 months (M=25.6). Seizure's control was observed in 7 (14.48%) patients taking 1200 mg/day and in 2 (4.16%) patients taking 1400 mg/day of CBZ. Thirty-nine patients did not show any control (81.21%). Ten patients (20.81%) had signs of intoxication. When patients have no improvement with 1400 mg/day, it is difficult to obtain any control despite the use of higher doses of CBZ, which frequently expose the patient to significant side effects. Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and fifteen on polytherapy. The other drugs were kept unchanged in the patients on polytherapy. The dose of CBZ was increased if no control was observed and the patient had no side effects. The doses used ranged between 1200 and 1900 mg/day (1200 mg/day, n = 18; 1300 mg/day, n = 1; 1400 mg/day, n = 7; 1600 mg/day, n = 9; 1700 mg/day, n = 4; 1800 mg/day, n = 8; 1900 mg/day, n = 1). Anticonvulsant plasma levels were taken to confirm patient compliance. The average plasma level was 9.6 ug/mL. The period of follow up varied from 3 to 96 months (M = 25.6). Seizure's control was observed in 7 (14.48%) patients taking 1200 mg/day and in 2 (4.16%) patients taking 1400 mg/day of CBZ. Thirty-nine patients did not show any control (81.21%). Ten patients (20.81%) had signs of intoxication. When patients have no improvement with 1400 mg/day, it is difficult to obtain any control despite the use of higher doses of CBZ, which frequently expose the patient to significant side effects. |
| Author | Borges Pereira, C Cukiert, A Otto Heise, C |
| AuthorAffiliation | Universidade de São Paulo |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8736143$$D View this record in MEDLINE/PubMed |
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| References | Cascino GD (ref4) 1994; 69 Pryse-Phillips W (ref20) 1982; 23 Guerreiro CAM (ref11) 1993; 51 Mattson RH (ref17) 1985; 313 Heller AJ (ref12) 1989; 30 Rodin EA (ref21) 1972; 13 Cornaggia CM (ref6) 1989; 11 Strandjord RE (ref24) 1980; 21 Van der Kleijn E (ref25) 1983 Jain KK (ref13) 1993; 86 Cabrini GP (ref1) 1979; 23 Pellock JM (ref19) 1991; 41 Gilman JT (ref10) 1994; 44 Elwes RDC (ref9) 1984; 311 Callaghan N (ref2) 1985; 48 Mattson RH (ref16) 1992; 327 Sillanpäa M (ref23) 1981; 64 Dooley JM (ref8) 1993; 20 Callaghan N (ref3) 1978; 41 Larkin JG (ref15) 1991; 32 Defazio G (ref7) 1991; 32 Shorvon SD (ref22) 1978; 1 Chadwick D (ref5) 1985; 48 Neufeld MY (ref18) 1993; 16 Kutt H (ref14) 1974; 31 Callaghan, N; Kenny, RA; O'Neill, B; Crowley, M; Goggin, T 1985; 48 Pryse-Phillips, W; Jardine, F; Bursey, F 1982; 23 Defazio, G; Lepore, V; Specchio, LM; Pisani, F; Livrea, P 1991; 32 Neufeld, MY 1993; 16 Jain, KK 1993; 86 Gilman, JT; Duchowny, M; Jayakar, P; Resnick, TJ 1994; 44 Chadwick, D; Turnbill, DM 1985; 48 Larkin, JG; Herrick, AL; McGuire, GM; Percy-Robb, IW; Brodie, MJ 1991; 32 Guerreiro, CAM; Ramos, MC; Annes, M 1993; 51 Callaghan, N; O'Callaghan, M; Duggan, B.; Feely, M 1978; 41 Rodin, EA 1972; 13 Mattson, RH; Cramer, JA; Collins, JF 1992; 327 Cascino, GD 1994; 69 Kutt, H; Penry, K 1974; 31 Strandjord, RE; Johannessen, SI 1980; 21 Cabrini, GP; Sironi, VA; Marossero, F; Baruzzi, A 1979; 23 Heller, AJ; Chesterman, P; Elwes, RDC; Reynolds, EH; Crawford, P; Chadwick, D; Johnson, AL 1989; 30 Mattson, RH; Cramer, JA; Collins, JF 1985; 313 Sillanpäa, M 1981; 64 Cornaggia, CM; Cattabeni, G; Cerisola, N; Leozappa, C; Mascetti, PL; Massioni, R; Porro, G; Manghi, E 1989; 11 Van der Kleijn, E; Schobben, F; Termond, E; Jansen, W; Vree, TB 1983 Dooley, JM; Camfield, PR; Camfield, CS; Gordon, KE; Fraser, AD 1993; 20 Pellock, JM; Willmore, LJ 1991; 41 Elwes, RDC; Jonhson, AL; Shorvon, SD; Reynolds, EH 1984; 311 Shorvon, SD; Chadwick, D; Galbraith, AW; Reynolds, EH 1978; 1 |
| References_xml | – volume: 23 start-page: 269 issn: 0013-9580 year: 1982 ident: ref20 article-title: Compliance with drug therapy by epileptic patients publication-title: Epilepsia doi: 10.1111/j.1528-1157.1982.tb06191.x contributor: fullname: Pryse-Phillips W – volume: 64 start-page: 69 issn: 0001-6314 year: 1981 ident: ref23 article-title: Carbamazepine: pharmacology and clinical uses publication-title: Acta Neurol Scand contributor: fullname: Sillanpäa M – volume: 86 start-page: 133 issn: 0141-0768 year: 1993 ident: ref13 article-title: Investigation and management of loss of efficacy of an antiepileptic medication using carbamazepine as an example publication-title: J R Soc Med doi: 10.1177/014107689308600305 contributor: fullname: Jain KK – volume: 16 start-page: 359 issn: 0362-5664 year: 1993 ident: ref18 article-title: Exacerbation of focal seizures due to carbamazepine treatment in an adult patient publication-title: Clin Neuropharmacol doi: 10.1097/00002826-199308000-00008 contributor: fullname: Neufeld MY – volume: 13 start-page: 121 issn: 0013-9580 year: 1972 ident: ref21 article-title: Medical and social prognosis in epilepsy publication-title: Epilepsia doi: 10.1111/j.1528-1157.1972.tb04559.x contributor: fullname: Rodin EA – volume: 41 start-page: 961 issn: 0028-3878 year: 1991 ident: ref19 article-title: A rational guide to routine blood monitoring in patients receiving antiepileptic drugs publication-title: Neurology doi: 10.1212/WNL.41.7.961 contributor: fullname: Pellock JM – start-page: 91 issn: 0001-6314 year: 1983 ident: ref25 article-title: Continuous monitoring of plasma antiepileptic drug levels publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.1983.tb01538.x contributor: fullname: Van der Kleijn E – volume: 313 start-page: 145 issn: 0028-4793 year: 1985 ident: ref17 article-title: Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures publication-title: N Engl J Med doi: 10.1056/NEJM198507183130303 contributor: fullname: Mattson RH – volume: 48 start-page: 639 issn: 0022-3050 year: 1985 ident: ref2 article-title: A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.48.7.639 contributor: fullname: Callaghan N – volume: 31 start-page: 283 issn: 0003-9942 year: 1974 ident: ref14 article-title: Usefulness of blood levels of antiepileptic drugs publication-title: Arch Neurol doi: 10.1001/archneur.1974.00490410031001 contributor: fullname: Kutt H – volume: 32 start-page: 89 issn: 0013-9580 year: 1991 ident: ref15 article-title: Antiepileptic drug monitoring at the epilepsy clinic: a prospective evaluation publication-title: Epilepsia doi: 10.1111/j.1528-1157.1991.tb05618.x contributor: fullname: Larkin JG – volume: 20 start-page: 217 issn: 0317-1671 year: 1993 ident: ref8 article-title: The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists publication-title: Can J Neurol Sci doi: 10.1017/S031716710004796X contributor: fullname: Dooley JM – volume: 1 start-page: 474 issn: 0007-1447 year: 1978 ident: ref22 article-title: One drug for epilepsy publication-title: Br Med J doi: 10.1136/bmj.1.6111.474 contributor: fullname: Shorvon SD – volume: 21 start-page: 655 issn: 0013-9580 year: 1980 ident: ref24 article-title: Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect publication-title: Epilepsia doi: 10.1111/j.1528-1157.1980.tb04319.x contributor: fullname: Strandjord RE – volume: 44 start-page: 1341 issn: 0028-3878 year: 1994 ident: ref10 article-title: Medical intractability in children evaluated for epilepsy surgery publication-title: Neurology doi: 10.1212/WNL.44.7.1341 contributor: fullname: Gilman JT – volume: 48 start-page: 1073 issn: 0022-3050 year: 1985 ident: ref5 article-title: The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.48.11.1073 contributor: fullname: Chadwick D – volume: 32 start-page: 706 issn: 0013-9580 year: 1991 ident: ref7 article-title: The infuence of eletroencephalographic focus laterality on efficacy of carbamazepine in complex partial and secondarily generalized tonic-clonic seizures publication-title: Epilepsia doi: 10.1111/j.1528-1157.1991.tb04713.x contributor: fullname: Defazio G – volume: 311 start-page: 944 issn: 0028-4793 year: 1984 ident: ref9 article-title: The prognosis for seizure in newly diagnosed epilepsy publication-title: N Engl J Med doi: 10.1056/NEJM198410113111503 contributor: fullname: Elwes RDC – volume: 41 start-page: 907 issn: 0022-3050 year: 1978 ident: ref3 article-title: Carbamazepine as a single drug in the treatment of epilepsy publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.41.10.907 contributor: fullname: Callaghan N – volume: 23 start-page: 29 issn: 0390-5616 year: 1979 ident: ref1 article-title: Indications of anticonvulsant plasma levels monitoring in medical and surgical treatment of epilepsy publication-title: J Neurosurg Sci contributor: fullname: Cabrini GP – volume: 327 start-page: 765 issn: 0028-4793 year: 1992 ident: ref16 article-title: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults publication-title: N Engl J Med doi: 10.1056/NEJM199209103271104 contributor: fullname: Mattson RH – volume: 11 start-page: 1 year: 1989 ident: ref6 article-title: Intractable epilepsies: an open trial with clobazam publication-title: Acta Neurol contributor: fullname: Cornaggia CM – volume: 30 start-page: 648 issn: 0013-9580 year: 1989 ident: ref12 article-title: Monotherapy for newly diagnosed adult epilepsy: comparative trial and prognostic evaluation publication-title: Epilepsia contributor: fullname: Heller AJ – volume: 69 start-page: 1199 issn: 0025-6196 year: 1994 ident: ref4 article-title: Epilepsy: contemporary perspectives on evaluation and treatment publication-title: Mayo Clin Proc doi: 10.1016/S0025-6196(12)65776-0 contributor: fullname: Cascino GD – volume: 51 start-page: 36 issn: 0004-282X year: 1993 ident: ref11 article-title: Dosagens séricas repetidas de anticonvulsivantes em pacientes epilépticas publication-title: Arq Neuropsiquiatr doi: 10.1590/S0004-282X1993000100006 contributor: fullname: Guerreiro CAM – volume: 31 start-page: 283 year: 1974 end-page: 288 article-title: Usefulness of blood levels of antiepileptic drugs publication-title: Arch Neurol contributor: fullname: Kutt, H; Penry, K – volume: 11 start-page: 1 year: 1989 end-page: 9 article-title: Intractable epilepsies: an open trial with clobazam publication-title: Acta Neurol contributor: fullname: Cornaggia, CM; Cattabeni, G; Cerisola, N; Leozappa, C; Mascetti, PL; Massioni, R; Porro, G; Manghi, E – volume: 32 start-page: 706 year: 1991 end-page: 711 article-title: The infuence of eletroencephalographic focus laterality on efficacy of carbamazepine in complex partial and secondarily generalized tonic-clonic seizures publication-title: Epilepsia contributor: fullname: Defazio, G; Lepore, V; Specchio, LM; Pisani, F; Livrea, P – volume: 44 start-page: 1341 year: 1994 end-page: 1343 article-title: Medical intractability in children evaluated for epilepsy surgery publication-title: Neurology contributor: fullname: Gilman, JT; Duchowny, M; Jayakar, P; Resnick, TJ – volume: 48 start-page: 1073 year: 1985 end-page: 1077 article-title: The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures publication-title: J Neurol Neurosurg Psychiatry contributor: fullname: Chadwick, D; Turnbill, DM – volume: 30 start-page: 648 year: 1989 article-title: Monotherapy for newly diagnosed adult epilepsy: comparative trial and prognostic evaluation publication-title: Epilepsia contributor: fullname: Heller, AJ; Chesterman, P; Elwes, RDC; Reynolds, EH; Crawford, P; Chadwick, D; Johnson, AL – volume: 23 start-page: 269 year: 1982 end-page: 274 article-title: Compliance with drug therapy by epileptic patients publication-title: Epilepsia contributor: fullname: Pryse-Phillips, W; Jardine, F; Bursey, F – volume: 23 start-page: 29 year: 1979 end-page: 36 article-title: Indications of anticonvulsant plasma levels monitoring in medical and surgical treatment of epilepsy publication-title: J Neurosurg Sci contributor: fullname: Cabrini, GP; Sironi, VA; Marossero, F; Baruzzi, A – volume: 313 start-page: 145 year: 1985 end-page: 151 article-title: Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures publication-title: N Engl J Med contributor: fullname: Mattson, RH; Cramer, JA; Collins, JF – volume: 32 start-page: 89 year: 1991 end-page: 95 article-title: Antiepileptic drug monitoring at the epilepsy clinic: a prospective evaluation publication-title: Epilepsia contributor: fullname: Larkin, JG; Herrick, AL; McGuire, GM; Percy-Robb, IW; Brodie, MJ – volume: 327 start-page: 765 year: 1992 end-page: 771 article-title: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults publication-title: N Engl J Med contributor: fullname: Mattson, RH; Cramer, JA; Collins, JF – volume: 21 start-page: 655 year: 1980 end-page: 662 article-title: Single-drug therapy with carbamazepine in patients with epilepsy: serum levels and clinical effect publication-title: Epilepsia contributor: fullname: Strandjord, RE; Johannessen, SI – volume: 69 start-page: 1199 year: 1994 end-page: 1211 article-title: Epilepsy: contemporary perspectives on evaluation and treatment publication-title: Mayo Clin Proc contributor: fullname: Cascino, GD – volume: 20 start-page: 217 year: 1993 end-page: 221 article-title: The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists publication-title: Can J Neurol Sci contributor: fullname: Dooley, JM; Camfield, PR; Camfield, CS; Gordon, KE; Fraser, AD – volume: 311 start-page: 944 year: 1984 end-page: 947 article-title: The prognosis for seizure in newly diagnosed epilepsy publication-title: N Engl J Med contributor: fullname: Elwes, RDC; Jonhson, AL; Shorvon, SD; Reynolds, EH – volume: 16 start-page: 359 year: 1993 end-page: 361 article-title: Exacerbation of focal seizures due to carbamazepine treatment in an adult patient publication-title: Clin Neuropharmacol contributor: fullname: Neufeld, MY – volume: 86 start-page: 133 year: 1993 end-page: 136 article-title: Investigation and management of loss of efficacy of an antiepileptic medication using carbamazepine as an example publication-title: J R Soc Med contributor: fullname: Jain, KK – volume: 41 start-page: 961 year: 1991 end-page: 964 article-title: A rational guide to routine blood monitoring in patients receiving antiepileptic drugs publication-title: Neurology contributor: fullname: Pellock, JM; Willmore, LJ – volume: 13 start-page: 121 year: 1972 end-page: 131 article-title: Medical and social prognosis in epilepsy publication-title: Epilepsia contributor: fullname: Rodin, EA – volume: 41 start-page: 907 year: 1978 end-page: 912 article-title: Carbamazepine as a single drug in the treatment of epilepsy publication-title: J Neurol Neurosurg Psychiatry contributor: fullname: Callaghan, N; O'Callaghan, M; Duggan, B.; Feely, M – volume: 51 start-page: 36 year: 1993 end-page: 40 article-title: Dosagens séricas repetidas de anticonvulsivantes em pacientes epilépticas publication-title: Arq Neuropsiquiatr contributor: fullname: Guerreiro, CAM; Ramos, MC; Annes, M – volume: 1 start-page: 474 year: 1978 end-page: 476 article-title: One drug for epilepsy publication-title: Br Med J contributor: fullname: Shorvon, SD; Chadwick, D; Galbraith, AW; Reynolds, EH – volume: 48 start-page: 639 year: 1985 end-page: 644 article-title: A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy publication-title: J Neurol Neurosurg Psychiatry contributor: fullname: Callaghan, N; Kenny, RA; O'Neill, B; Crowley, M; Goggin, T – start-page: 91 year: 1983 end-page: 114 article-title: Continuous monitoring of plasma antiepileptic drug levels publication-title: Acta Neurol Scand contributor: fullname: Van der Kleijn, E; Schobben, F; Termond, E; Jansen, W; Vree, TB – volume: 64 start-page: 69 year: 1981 end-page: 76 article-title: Carbamazepine: pharmacology and clinical uses publication-title: Acta Neurol Scand contributor: fullname: Sillanpäa, M |
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| Snippet | Forty-eight patients with partial seizures were analysed during treatment with 1200 mg/d or more of carbamazepine (CBZ). Thirty-three were on monotherapy and... |
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| SubjectTerms | Adolescent Adult Anticonvulsants - administration & dosage Carbamazepine - administration & dosage Epilepsies, Partial - drug therapy Female Follow-Up Studies Humans Male Middle Aged NEUROSCIENCES PSYCHIATRY Retrospective Studies Treatment Outcome |
| Title | High doses of carbamazepine for refractory partial epilepsy |
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