It’s noisy out there! A review of denoising techniques in cryo-electron tomography

• Published in: Journal of structural biology Vol. 213; no. 4; p. 107804
• Main Author: Frangakis, Achilleas S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021
• Subjects: Algorithms; Cryoelectron Microscopy - methods; Electron Microscope Tomography - methods; Image Processing, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Neural Networks, Computer; Reproducibility of Results; Signal-To-Noise Ratio; Software

Cryo-electron tomography is the only technique that can provide sub-nanometer resolved images of cell regions or even whole cells, without the need of labeling or staining methods. Technological advances over the past decade in electron microscope stability, cameras, stage precision and software hav...