Induction of transgenerational toxicity is associated with the activated germline insulin signals in nematodes exposed to nanoplastic at predicted environmental concentrations

• Published in: Ecotoxicology and environmental safety Vol. 243; p. 114022
• Main Authors: Liu, Huanliang, Zhao, Yunli, Hua, Xin, Wang, Dayong
• Format: Journal Article
• Language: English
• Published: Elsevier 15.09.2022
• Subjects: C. elegans; Insulin signal; Nanopolystyrene; Transgenerational toxicity

Exposure to nanoplastics can induce toxicity on organisms at both parental generation (P0-G) and the offspring. However, the underlying mechanism remains unknown. Using Caenorhabditis elegans as a model organism, exposure to 20-nm polystyrene nanoparticle (PS-NP) (1-100 μg/L) upregulated the express...