Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate

• Published in: Folia microbiologica Vol. 58; no. 3; pp. 219 - 224
• Main Authors: Fundová, P, Funda, D. P, Kovář, D, Holý, R, Navara, M, Tlaskalová-Hogenová, H
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer-Verlag 01.05.2013; Springer Netherlands; Springer Nature B.V
• Subjects: Applied Microbiology; Biomedical and Life Sciences; biopsy; CCR1 receptor; CCR3 receptor; Chemokines; Cytokines; Environmental Engineering/Biotechnology; eosinophils; Eosinophils - cytology; etiology; fluorescence microscopy; Granulocytes - cytology; Humans; image analysis; Immunohistochemistry; Immunology; Life Sciences; Microbiology; nasal mucosa; Nasal Mucosa - metabolism; Nasal Mucosa - pathology; Nasal Polyps - genetics; Nasal Polyps - metabolism; Nasal Polyps - pathology; Pathogenesis; polyps (pathological conditions); protein synthesis; Receptors, CCR1 - genetics; Receptors, CCR1 - metabolism; Receptors, CCR3 - genetics; Receptors, CCR3 - metabolism; Nasal Mucosa; Nasal Polyposis; Inferior Turbinate; Chemokine Receptor; Nasal Polyp

Inflammatory processes play an important role in the development of nasal polyps (NP), but the etiology and, to a high degree also, the pathogenesis of NP are not fully understood. The role of several cytokines and chemokines such as eotaxins, IL-4, IL-5, IL-6, IL-8, and RANTES has been reported in...