Health promoting effects of Lupin (Lupinus albus var. multolupa) protein hydrolyzate and insoluble fiber in a diet-induced animal experimental model of hypercholesterolemia

New functional foods are increasingly sought to improve the treatment of diseases related to glucose and lipid metabolism. Lupin (Lupinus albus) is an excellent candidate since it exhibits several health-promoting effects. Such beneficial effects can be enhanced by technological treatments like prot...

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Published inFood research international Vol. 54; no. 2; pp. 1471 - 1481
Main Authors Kapravelou, Garifalia, Martínez, Rosario, Andrade, Ana M., Sánchez, Cristina, Chaves, Carlos López, López-Jurado, María, Aranda, Pilar, Cantarero, Samuel, Arrebola, Francisco, Fernández-Segura, Eduardo, Galisteo, Milagros, Porres, Jesús M.
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.12.2013
Elsevier
Subjects
animals
Aspergillus oryzae
Bacillus licheniformis
Biological and medical sciences
excretion
Fibers
Food industries
functional foods
Fundamental and applied biological sciences. Psychology
Glucose
health promotion
hydrolysis
hypercholesterolemia
Insoluble fiber
Intestines
large intestine
Large intestine functionality
Lipid metabolism
Lupin
Lupins
Lupinus albus
Mathematical models
physiological state
Protease
Protein hydrolyzate
proteinases
Proteins
Renal alterations
Residues
triacylglycerols
water holding capacity
Insoluble fiber
Protein hydrolyzate
Lupin
Large intestine functionality
Lipid metabolism
Renal alterations
Animal model
Health
Fiber
Alteration
Lipids
Metabolism
Protein
Hypercholesterolemia
Functionality
Hydrolysate
Diet
Large intestine
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Abstract New functional foods are increasingly sought to improve the treatment of diseases related to glucose and lipid metabolism. Lupin (Lupinus albus) is an excellent candidate since it exhibits several health-promoting effects. Such beneficial effects can be enhanced by technological treatments like protein hydrolysis with microbial proteases. The aim of this study was to assess the effect of lupin protein hydrolyzate, combined or not with lupin insoluble fiber, on different plasmatic, hepatic, renal and large intestine parameters using an in vivo experimental model of diet-induced hypercholesterolemia. Lupin protein hydrolyzate and insoluble fiber residue were obtained by aqueous protein extraction and sequential hydrolysis with proteases from Bacillus licheniformis and Aspergillus oryzae. The protein hydrolyzate was effective at reducing plasma and hepatic triglycerides, and showed promising effects on glucose metabolism as well as protection against dietary-induced renal alterations. The insoluble fiber residue increased fecal fat excretion, and improved parameters of large intestine physiological status due to its fermentative and water holding capacity. •Lupin protein hydrolyzayte was obtained by digestion with recombinant proteases.•An experimental model of diet-induced hypercholesterolemia was developed in rats.•Lupin protein hydrolyzate decreased plasmatic glucose and triglycerides.•Lupin protein hydrolyzate decreased liver content of cholesterol and triglycerides.•Lupin insoluble fiber residue improved parameters of large intestine functionality.
AbstractList New functional foods are increasingly sought to improve the treatment of diseases related to glucose and lipid metabolism. Lupin (Lupinus albus) is an excellent candidate since it exhibits several health-promoting effects. Such beneficial effects can be enhanced by technological treatments like protein hydrolysis with microbial proteases. The aim of this study was to assess the effect of lupin protein hydrolyzate, combined or not with lupin insoluble fiber, on different plasmatic, hepatic, renal and large intestine parameters using an in vivo experimental model of diet-induced hypercholesterolemia. Lupin protein hydrolyzate and insoluble fiber residue were obtained by aqueous protein extraction and sequential hydrolysis with proteases from Bacillus licheniformis and Aspergillus oryzae. The protein hydrolyzate was effective at reducing plasma and hepatic triglycerides, and showed promising effects on glucose metabolism as well as protection against dietary-induced renal alterations. The insoluble fiber residue increased fecal fat excretion, and improved parameters of large intestine physiological status due to its fermentative and water holding capacity. •Lupin protein hydrolyzayte was obtained by digestion with recombinant proteases.•An experimental model of diet-induced hypercholesterolemia was developed in rats.•Lupin protein hydrolyzate decreased plasmatic glucose and triglycerides.•Lupin protein hydrolyzate decreased liver content of cholesterol and triglycerides.•Lupin insoluble fiber residue improved parameters of large intestine functionality.
New functional foods are increasingly sought to improve the treatment of diseases related to glucose and lipid metabolism. Lupin (Lupinus albus) is an excellent candidate since it exhibits several health-promoting effects. Such beneficial effects can be enhanced by technological treatments like protein hydrolysis with microbial proteases. The aim of this study was to assess the effect of lupin protein hydrolyzate, combined or not with lupin insoluble fiber, on different plasmatic, hepatic, renal and large intestine parameters using an in vivo experimental model of diet-induced hypercholesterolemia. Lupin protein hydrolyzate and insoluble fiber residue were obtained by aqueous protein extraction and sequential hydrolysis with proteases from Bacillus licheniformis and Aspergillus oryzae. The protein hydrolyzate was effective at reducing plasma and hepatic triglycerides, and showed promising effects on glucose metabolism as well as protection against dietary-induced renal alterations. The insoluble fiber residue increased fecal fat excretion, and improved parameters of large intestine physiological status due to its fermentative and water holding capacity.
Author López-Jurado, María
Galisteo, Milagros
Chaves, Carlos López
Sánchez, Cristina
Porres, Jesús M.
Cantarero, Samuel
Martínez, Rosario
Aranda, Pilar
Kapravelou, Garifalia
Andrade, Ana M.
Fernández-Segura, Eduardo
Arrebola, Francisco
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  givenname: Pilar
  surname: Aranda
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  organization: Department of Physiology, Institute of Nutrition and Food Technology, Doctoral Program in Nutrition and Food Sciences, University of Granada, Campus Universitario de Cartuja s/n., Granada 18071, Spain
– sequence: 8
  givenname: Samuel
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  fullname: Cantarero, Samuel
  organization: Centro de Instrumentación Científica, Universidad de Granada, Campus Universitario de Fuentenueva s/n., Granada 18071, Spain
– sequence: 9
  givenname: Francisco
  surname: Arrebola
  fullname: Arrebola, Francisco
  organization: Department of Histology, Institute of Neurosciences, University of Granada, Avenida de Madrid s/n., Granada 18071, Spain
– sequence: 10
  givenname: Eduardo
  surname: Fernández-Segura
  fullname: Fernández-Segura, Eduardo
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  givenname: Milagros
  surname: Galisteo
  fullname: Galisteo, Milagros
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  givenname: Jesús M.
  surname: Porres
  fullname: Porres, Jesús M.
  email: jmporres@ugr.es
  organization: Department of Physiology, Institute of Nutrition and Food Technology, Doctoral Program in Nutrition and Food Sciences, University of Granada, Campus Universitario de Cartuja s/n., Granada 18071, Spain
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Issue 2
Keywords Insoluble fiber
Protein hydrolyzate
Lupin
Large intestine functionality
Lipid metabolism
Renal alterations
Animal model
Health
Fiber
Alteration
Lipids
Metabolism
Protein
Hypercholesterolemia
Functionality
Hydrolysate
Diet
Large intestine
Language English
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Snippet New functional foods are increasingly sought to improve the treatment of diseases related to glucose and lipid metabolism. Lupin (Lupinus albus) is an...
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SubjectTerms animals
Aspergillus oryzae
Bacillus licheniformis
Biological and medical sciences
excretion
Fibers
Food industries
functional foods
Fundamental and applied biological sciences. Psychology
Glucose
health promotion
hydrolysis
hypercholesterolemia
Insoluble fiber
Intestines
large intestine
Large intestine functionality
Lipid metabolism
Lupin
Lupins
Lupinus albus
Mathematical models
physiological state
Protease
Protein hydrolyzate
proteinases
Proteins
Renal alterations
Residues
triacylglycerols
water holding capacity
Title Health promoting effects of Lupin (Lupinus albus var. multolupa) protein hydrolyzate and insoluble fiber in a diet-induced animal experimental model of hypercholesterolemia
URI https://dx.doi.org/10.1016/j.foodres.2013.10.019
https://search.proquest.com/docview/1671546143
Volume 54
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