Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

• Published in: Brain, behavior, and immunity Vol. 80; pp. 88 - 108
• Main Authors: Tyebji, Shiraz, Seizova, Simona, Garnham, Alexandra L., Hannan, Anthony J., Tonkin, Christopher J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.08.2019
• Subjects: Cognitive impairment; Neuronal activation; Sociability; Social memory; Synaptic signalling; Toxoplasma gondii; Sociability; Toxoplasma gondii; Social memory; Synaptic signalling; Cognitive impairment; Neuronal activation

•Chronic T. gondii infection in mice impairs sociability, social recognition memory.•Neuronal activation upon social interaction is impaired in relevant brain regions.•Functional connectivity in the brain is altered after chronic T. gondii infection.•Infection leads to a dysregulation of synaptic si...