Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes

• Published in: Chemico-biological interactions Vol. 327; p. 109148
• Main Authors: Tsugoshi, Yukie, Watanabe, Yoko, Tanikawa, Yuka, Inoue, Chika, Sugihara, Kazumi, Kojima, Hiroyuki, Kitamura, Shigeyuki
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.08.2020
• Subjects: Carboxylesterase; Inhibition; Organophosphate esters; Rat liver microsomes; Organophosphate esters; Inhibition; Carboxylesterase; Rat liver microsomes

We investigated the inhibitory effects of 13 organophosphate esters (OPEs) and hydrolytic metabolites on the carboxylesterase activity of rat liver microsomes in vitro in order to examine whether there might be a potential impact on human health, and to elucidate the structure activity relationship....