Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes

• Published in: The Journal of immunology (1950) Vol. 208; no. 3; pp. 594 - 602
• Main Authors: Jones, Britta E., Maerz, Megan D., Bahnson, Henry T., Somasundaram, Ashwin, McCarthy, Lucas H., Speake, Cate, Buckner, Jane H.
• Format: Journal Article
• Language: English
• Published: United States 01.02.2022
• Subjects: Antigens, CD - metabolism; Apoptosis - physiology; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Proliferation - physiology; Diabetes Mellitus, Type 1 - immunology; Gene Expression Regulation - genetics; Humans; Lymphocyte Activation - immunology; Lymphocyte Activation Gene 3 Protein; Multiple Sclerosis, Relapsing-Remitting - immunology; RNA, Messenger - biosynthesis

The coinhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint molecule that negatively regulates T cell activation, proliferation, and homeostasis. Blockade or deletion of LAG-3 in autoimmune-prone backgrounds or induced-disease models has been shown to exacerbate disease. W...