Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3

• Published in: Bioorganic & medicinal chemistry Vol. 95; p. 117507
• Main Authors: Shih, Po-Chang, Naganuma, Miyako, Tsuji, Genichiro, Demizu, Yosuke, Naito, Mikihiko
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15.11.2023
• Subjects: degrader therapeutics; nucleic acids; PROTAC; proteases; SNIPER; STAT3; targeted protein degradation; SNIPER; PROTAC; proteases; STAT3; degrader therapeutics; targeted protein degradation; nucleic acids

[Display omitted] Proteolysis-targeting chimera (PROTAC) technology is a disruptive innovation in the drug development community, and over 20 PROTAC molecules are currently under clinical evaluation. These PROTAC molecules contain small-molecule warheads that bind to target proteins. Recently, oligo...