Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis

• Published in: World journal of gastroenterology : WJG Vol. 23; no. 25; pp. 4644 - 4653
• Main Authors: Shin, Mi-Rae, An, Hyo-Jin, Seo, Bu-Il, Roh, Seong-Soo
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 07.07.2017
• Subjects: Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Apoptosis - drug effects; Disease Models, Animal; Esophageal Mucosa - drug effects; Esophageal Mucosa - metabolism; Esophageal Mucosa - pathology; Esophagitis, Peptic - drug therapy; Esophagitis, Peptic - pathology; Evidence-Based Medicine; Humans; JNK Mitogen-Activated Protein Kinases - metabolism; Male; Medicine, Chinese Traditional - methods; NADPH Oxidases - metabolism; Oxidative Stress - drug effects; Phytotherapy - methods; Plant Preparations - pharmacology; Plant Preparations - therapeutic use; Plants, Medicinal - chemistry; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Tumor Necrosis Factor-alpha - metabolism; Reactive oxygen species; Chronic acid reflux esophagitis; Esophageal ulcer; Banhasasim-tang; Apoptosis

To evaluate the anti-apoptotic effect of banhasasim-tang (BHSST) on chronic acid reflux esophagitis (CARE) using a rat model. A surgically-induced CARE model was established in Sprague-Dawley rats. The modeled rats were divided into a treatment group or untreated group, and given BHSST (1 g/kg body...