Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes

• Published in: Hearing research Vol. 380; pp. 137 - 149
• Main Authors: Pinyon, Jeremy L., von Jonquieres, Georg, Crawford, Edward N., Duxbury, Mayryl, Al Abed, Amr, Lovell, Nigel H., Klugmann, Matthias, Wise, Andrew K., Fallon, James B., Shepherd, Robert K., Birman, Catherine S., Lai, Waikong, McAlpine, David, McMahon, Catherine, Carter, Paul M., Enke, Ya Lang, Patrick, James F., Schilder, Anne G.M., Marie, Corinne, Scherman, Daniel, Housley, Gary D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2019; Elsevier
• Subjects: Animals; Auditory nerve fibre regeneration; Auditory Perception - genetics; Bionic array directed gene electrotransfer; Biotechnology; Brain derived neurotrophic factor; Cochlear Implantation - instrumentation; Cochlear Implants; Combined Modality Therapy; Electroporation; Gene therapy; Gene Transfer Techniques; Genetic Therapy; Hearing - genetics; Hearing Loss - genetics; Hearing Loss - physiopathology; Hearing Loss - psychology; Hearing Loss - rehabilitation; Human health and pathology; Humans; Life Sciences; Nerve Growth Factors - genetics; Neurotrophin-3; Persons with Hearing Disabilities - psychology; Persons with Hearing Disabilities - rehabilitation; Recovery of Function; Sensorineural hearing loss; Sensory Organs; Treatment Outcome; Up-Regulation; Neurotrophin-3; Brain derived neurotrophic factor; Auditory nerve fibre regeneration; Bionic array directed gene electrotransfer; Gene therapy; Sensorineural hearing loss; SURVIVAL; HAIR-CELLS; SPIRAL GANGLION NEURONS; INNER-EAR; THERAPY; INTRACOCHLEAR ELECTRICAL-STIMULATION; MOUSE MODEL; WORD RECOGNITION; EXPRESSION; DELIVERY

This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the potential to utilize the properties of recombinant neurotrophins to improve cochlear auditory (spiral ganglion) neuron survival and repair. This potential to reduce spiral g...